| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this study, we investigated whether C-type natriuretic peptide (CNP) functions to regulate follicular development and atresia. The numbers of ovarian follicles in mice injected with CNP and CNP transgenic mice showed no difference compared with those of normal mice. We showed the expression of Npr3 gene in granulosa cells of ovarian follicles, but no alterations were observed in the ovary of mice with a mutation in Npr3 gene. Next, we investigated CNP function in cultured early antral follicles, and found that a moderate inhibitory effect of CNP on apoptosis in granulosa cells. We conclude that CNP may have the potential to control follicular atresia via inhibition of apoptosis in granulosa cells.
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