Possible countermeasures against age-associated deteriorations of bovine oocytes
| Project/Area Number |
25450400
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 加齢 / 卵子 / ミトコンドリア / 卵胞液 / 顆粒層細胞 / SIRT1 / 発生 / 初期胞状卵胞卵子 / オートファージ |
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| Outline of Final Research Achievements |
Present study investigated casual factors of the age associated deterioration of oocytes by using cows as a model animal, and showed that granulosa cells and follicular fluids of aged cows induced dysfunctions of oocytes. Results obtained in this study suggest that given granulosa cells and follicular fluid are replaced with those derived from younger cows, developmental competence of the oocytes derived from aged cows would improve. In addition, present study demonstrated the presence of mitochondrial quality control system in oocytes, through which oocytes replenish mitochondria in response to induced mitochondrial dysfunctions. In addition, present study showed that resveratrol induced mitochondrial replenishment by enhancing mitochondrial quality control system.
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Report
(4 results)
Research Products
(31 results)
