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Computational analysis of a conformational epitope of a broadly neutralizing antibody in influenza A virus hemagglutinin

Research Project

Project/Area Number 25450417
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionHokkaido University

Principal Investigator

Igarashi Manabu  北海道大学, 人獣共通感染症リサーチセンター, 准教授 (10374240)

Co-Investigator(Renkei-kenkyūsha) TAKADA AYATO  北海道大学, 人獣共通感染症リサーチセンター, 教授 (10292062)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsインフルエンザ / ウイルス / 抗体 / 計算科学 / 分子動力学 / 分子モデリング / 分子動力学計算 / 分子間相互作用 / ホモロジーモデリング
Outline of Final Research Achievements

The HA of influenza A viruses is classified into 16 subtypes (H1-H16). We have previously reported a cross-reactive antibody, designated S139/1, which neutralizes H1, H2, H3, H13, and H16 subtypes. In this study, we characterized the S139/1 recognition sites on different HAs by computational methods such as molecular modeling and dynamics simulations. We investigated the contribution of individual residues on each HA to the interaction with S139/1, and found that amino acids at 10 positions on HA strongly contributed to S139/1 binding as for the strains neutralized by S139/1. Analysis of hydrogen bond interactions emphasized that the residues at positions 156, 158 and 193 were the most important for S139/1 binding. Indeed, amino acid substitutions at these three positions were experimentally observed in the mutant viruses escaping from neutralization by S139/1. Thus, our computational methods identified the amino acid residues critical for the cross-neutralizing activity of S139/1.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (51 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (13 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 12 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (36 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Remarks (2 results)

  • [Journal Article] Genetic predisposition to acquire a polybasic cleavage site for highly pathogenic avian influenza virus hemagglutinin2017

    • Author(s)
      Nao N, Yamagishi J, Miyamoto H, Igarashi M, Manzoor R, Ohnuma A, Tsuda Y, Furuyama W, Shigeno A, Kajihara M, Kishida N, Yoshida R, Takada A
    • Journal Title

      MBio

      Volume: 8 Issue: 1 Pages: 1-15

    • DOI

      10.1128/mbio.02298-16

    • NAID

      120006337761

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fcγ-receptor IIa-mediated Src signaling pathway is essential for the antibody-dependent enhancement of Ebola virus infection2016

    • Author(s)
      Furuyama W, Marzi A, Carmody AB, Maruyama J, Kuroda M, Miyamoto H, Nanbo A, Manzoor R, Yoshida R, Igarashi M, Feldmann H, Takada A
    • Journal Title

      PLoS Pathog.

      Volume: 12 Issue: 12 Pages: e1006139-e1006139

    • DOI

      10.1371/journal.ppat.1006139

    • NAID

      120005981447

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Discovery of an antibody for pan-ebolavirus therapy2016

    • Author(s)
      Furuyama D, Marzi A, Nanbo A, Haddock E, Maruyama J, Miyamoto H, Igarashi M, Yoshida R, Dr. Noyori O, Feldmann H, Takada A
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 20514-20514

    • DOI

      10.1038/srep20514

    • NAID

      120005906783

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of the glycoproteins of bat-derived influenza viruses.2016

    • Author(s)
      Maruyama J, Nao N, Miyamoto H, Maeda K, Ogawa H, Yoshida R, Igarashi M, Takada A
    • Journal Title

      Virology

      Volume: 488 Pages: 43-50

    • DOI

      10.1016/j.virol.2015.11.002

    • NAID

      120005906991

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amino acid residues at positions 222 and 227 of the hemagglutinin together with the neuraminidase determine binding of H5 avian influenza viruses to sialyl Lewis X2016

    • Author(s)
      Hiono T, Okamatsu M, Igarashi M, McBride R, de Vries RP, Peng W, Paulson JC, Sakoda Y, Kida H
    • Journal Title

      Arch Virol

      Volume: 161(2) Issue: 2 Pages: 307-316

    • DOI

      10.1007/s00705-015-2660-3

    • NAID

      120006661332

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antiviral Drugs Targeting Influenza Virus Surface Proteins: A Computational Structural Biology Approach2015

    • Author(s)
      Igarashi M
    • Journal Title

      Yakugaku Zasshi

      Volume: 135(9) Pages: 1015-1021

    • NAID

      130005096687

    • Related Report
      2015 Research-status Report
  • [Journal Article] A Single Amino Acid in the M1 Protein Responsible for the Different Pathogenic Potentials of H5N1 Highly Pathogenic Avian Influenza Virus Strains2015

    • Author(s)
      Nao N, Kajihara M, Manzoor R, Maruyama J, Yoshida R, Muramatsu M, Miyamoto H, Igarashi M, Eguchi N, Sato M, Kondoh T, Okamatsu M, Sakoda Y, Kida H, Takada A
    • Journal Title

      PLoS One

      Volume: 10(9) Issue: 9 Pages: e0137989-e0137989

    • DOI

      10.1371/journal.pone.0137989

    • NAID

      120005672370

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates2015

    • Author(s)
      Itoh Y, Shichinohe S, Nakayama M, Igarashi M, Ishii A, Ishigaki H, Ishida H, Kitagawa N, Sasamura T, Shiohara M, Doi M, Tsuchiya H, Nakamura S, Okamatsu M, Sakoda Y, Kida H, Ogasawara K
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 59(8) Issue: 8 Pages: 4962-4973

    • DOI

      10.1128/aac.00793-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Critical Determinant of Neurological Disease Associated with Highly Pathogenic Tick-borne Flavivirus in Mice2014

    • Author(s)
      Yoshii K, Sunden Y, Yokozawa K, Igarashi M, Kariwa H, Holbrook MR, Takashima I.
    • Journal Title

      Journal of Virology

      Volume: 88 Issue: 10 Pages: 5406-5420

    • DOI

      10.1128/jvi.00421-14

    • NAID

      120005496501

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The zoonotic potential of avian influenza viruses isolated from wild waterfowl in Zambia2014

    • Author(s)
      Simulundu E, Nao N, Yabe J, Muto NA, Sithebe T, Sawa H, Manzoor R, Kajihara M, Muramatsu M, Ishii A, Ogawa H, Mweene AS, Takada A
    • Journal Title

      Arch. Virol.

      Volume: 159 Issue: 6 Pages: 2633-2640

    • DOI

      10.1371/journal.ppat.1004192

    • NAID

      120005656330

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential potential for envelope gycoprotein-mediated steric shielding of host cell surface proteins among filoviruses2013

    • Author(s)
      Noyori Osamu
    • Journal Title

      Virology

      Volume: 446 Issue: 1-2 Pages: 152-161

    • DOI

      10.1016/j.virol.2013.07.029

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cysteine Residues in the Major Capsid Protein, Vp1, of the JC Virus Are Important for Protein Stability and Oligomer Formation2013

    • Author(s)
      Kobayashi S, Suzuki T, Igarashi M, Orba Y, Ohtake N, Nagakawa K, Niikura K, Kimura T, Kasamatsu H, Sawa H
    • Journal Title

      PLoS One

      Volume: 8(10) Issue: 10 Pages: e76668-e76668

    • DOI

      10.1371/journal.pone.0076668

    • NAID

      120005350093

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] High prevalence of spotted fever group rickettsiae in Amblyomma variegatum from Uganda and their identification using sizes of intergenic spacers2013

    • Author(s)
      Nakao R, Qiu Y, Igarashi M, Magona JW, Zhou L, Ito K, Sugimoto C
    • Journal Title

      Ticks and Tick-Borne Disease

      Volume: 4(6) Issue: 6 Pages: 506-512

    • DOI

      10.1016/j.ttbdis.2013.07.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Generation of a cross-neutralizing monoclonal antibody against all known ebolavirus species2016

    • Author(s)
      Furuyama W, Marzi A, Nanbo A, Haddock E, Maruyama J, Miyamoto H, Igarashi M, Yoshida R, Noyori O, Feldmann H, Takada A
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      北海道札幌市、札幌コンベンションセンター
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Genetic Predisposition to Acquire a Polybasic Cleavage Site for Highly Pathogenic Avian Influenza Virus Hemagglutinin2016

    • Author(s)
      Nao N, Yamagishi J, Miyamoto H, Igarashi M, Manzoor R, Ohnuma A, Tsuda Y, Furuyama W, Kajihara M, Yoshida R, Takada A
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      北海道札幌市、札幌コンベンションセンター
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Characterization of glycoprotein of Severe fever with thrombocytopenia syndrome virus2016

    • Author(s)
      Nishigami K, Tsuda Y, Nishio S, Igarashi M, Yoshimatsu K, Arikawa J
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      北海道札幌市、札幌コンベンションセンター
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Computational analysis of a conformational epitope of a broadly neutralizing antibody in influenza A virus hemagglutinin2016

    • Author(s)
      Igarashi M, Sekijima M, Yasuo N, Abe T, Yoshida R, Tokiwa H, Watabe T, Hirokawa T, Takada A
    • Organizer
      Options IX for the Control of Influenza
    • Place of Presentation
      Chicago, Illinois, USA
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular analysis on receptor-binding of H5 influenza viruses to fucosylated α2,3 sialosides2016

    • Author(s)
      Hiono T, Okamatsu M, Igarashi M, McBride R, de Vries RP, Peng W, Paulson J, Sakoda Y, Kida H
    • Organizer
      Options IX for the Control of Influenza
    • Place of Presentation
      Chicago, Illinois, USA
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A genetic basis for the acquisition of basic amino acid residues at the cleavage site of influenza virus hemagglutinin2016

    • Author(s)
      Nao N, Yamagishi J, Miyamoto H, Ohnuma A, Furuyama W, Tsuda Y, Manzoor R, Yoshida R, Igarashi M, Takada A
    • Organizer
      Options IX for the Control of Influenza
    • Place of Presentation
      Chicago, Illinois, USA
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 人獣共通感染症研究における計算科学の活用2016

    • Author(s)
      五十嵐 学
    • Organizer
      第374回CBI学会講演会「感染症研究の将来~グローバルヘルスに貢献する創薬~」
    • Place of Presentation
      東京都文京区、東京大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Computational analysis of common epitope recognized by a broadly neutralizing monoclonal antibody against influenza A virus hemagglutini2015

    • Author(s)
      五十嵐学、関嶋政和、安尾信明、阿部貴志、吉田玲子、渡部輝明、石坪江梨花、常盤広明、広川貴次、高田礼人
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡県福岡市 福岡国際会議場
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 計算科学的アプローチによる人獣共通感染症研究2015

    • Author(s)
      五十嵐学
    • Organizer
      琉球大学熱帯生物圏研究センター共同利用研究会
    • Place of Presentation
      沖縄県中頭郡西原町 琉球大学
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Computational analysis of a conformational epitope of a broadly neutralizing antibody in influenza A virus hemagglutinin2015

    • Author(s)
      五十嵐学、関嶋政和、安尾信明、阿部貴志、渡部輝明、常盤広明、広川貴次、高田礼人
    • Organizer
      CBI学会2015年大会
    • Place of Presentation
      東京都江戸川区 タワーホール船堀
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
  • [Presentation] インフルエンザウイルスHAタンパク質のpH依存性構造変化に関する分子シミュレーション研究2015

    • Author(s)
      三浦信明、五十嵐学
    • Organizer
      第9回分子科学討論会
    • Place of Presentation
      東京都目黒区 東京工業大学
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report
  • [Presentation] インフルエンザの制御と計算科学2015

    • Author(s)
      五十嵐学
    • Organizer
      第9回CBI学会FMO研究会
    • Place of Presentation
      東京都港区 東京工業大学キャンパスイノベーションセンター
    • Year and Date
      2015-05-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 新規マルチターゲット抗インフルエンザウイルス阻害剤の構造活性相関研究(1)2015

    • Author(s)
      横田智洋、細沢拓未、石坪江梨花、加藤裕也、五十嵐学、KIRSHNER Karil N、SLIWILAIJAROEN Nongluk、横江弘雅、鈴木康夫、常盤広明、津吹政可
    • Organizer
      第135回日本薬学会年会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 新規マルチターゲット抗インフルエンザウイルス阻害剤の構造活性相関研究(2)2015

    • Author(s)
      加藤裕也、細沢拓未、石坪江梨花、横田智洋、五十嵐学、KIRSHNER Karil N、SLIWILAIJAROEN Nongluk、横江弘雅、鈴木康夫、常盤広明、津吹政可
    • Organizer
      第135回日本薬学会年会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 梅エキス抽出物をリードとした新規マルチターゲット抗インフルエンザ薬の合理的設計開発2015

    • Author(s)
      石坪江梨花、細沢拓未、五十嵐学、KIRSHNER Karl N、SRIWILAIJAROEN Nongluk、横江弘雅、津吹政可、鈴木康夫、常盤広明
    • Organizer
      第135回日本薬学会年会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 食品由来の天然物を先導化合物とした新規マルチターゲット抗インフルエンザ薬の合理的設計開発2014

    • Author(s)
      石坪江梨花、五十嵐学、Karl N. Kirshner、Nongluk Sriwilaijaroen、細沢拓未、横江弘雅、津吹政可、鈴木康夫、常盤広明
    • Organizer
      第32回メディシナルケミストリーシンポジウム
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2014-11-26 – 2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of Novel Multi-target Inhibitor for HA & NA of Influenza Virus2014

    • Author(s)
      Ishitsubo E, Hosozawa T, Igarashi M, Kirshner KN, Sriwilaijaroen N, Yokoe H, Tubuki M, Suzuki Y, Tokiwa H
    • Organizer
      Joint Meeting of the Society for Glycobiology (SFG) and the Japanse Society of Carbonhydrates Research (JSCR)
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] H5N1 インフルエンザウイルスに対する中和抗体を用いた受動免疫の感染防御効果2014

    • Author(s)
      吉田玲子、伊藤靖、七戸新太郎、小笠原一誠、日尾野隆大、岡松正敏、迫田義博、喜田宏、Mai Quynh Le、河岡義裕、五十嵐学、鈴木定彦、高田礼人
    • Organizer
      第62回ウイルス学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 遺伝子配列データをリサンプリングするウェブアプリケーションの構築2014

    • Author(s)
      米澤弘毅、五十嵐学、小原康夫、伊藤公人
    • Organizer
      第62回ウイルス学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗インフルエンザウイルス活性を有する天然物の多面性効果に関する高精度in silico解析2014

    • Author(s)
      石坪江梨花、五十嵐学、Karl N. Kirshner、Nongluk Sriwilaijaroen、細沢拓未、横江弘雅、津吹政可、鈴木康夫、常盤広明
    • Organizer
      第62回ウイルス学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] ニワトリのインフルエンザウイルスはフコシル化および硫酸化α2,3 シアル酸糖鎖をレセプターとする2014

    • Author(s)
      岡松正敏、日尾野隆大、五十嵐学、Robert de Vries、西原祥子、高瀬明、James C. Paulson、迫田義博、喜田宏
    • Organizer
      第62回ウイルス学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of Novel Multi-target Inhibitor for HA & NA of Influenza Virus2014

    • Author(s)
      Ishitsubo E, Hosozawa T, Igarashi M, Kirshner KN, Sriwilaijaroen N, Yokoe H, Tubuki M, Suzuki Y, Tokiwa H
    • Organizer
      2nd International Conference on Pharma and Food
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2014-11-05 – 2014-11-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Rational Drug Design of Novel anti-Influenza inhibitors based on Fragment Orbital Method and MD Simulations2014

    • Author(s)
      Ishitsubo E, Hosozawa T, Igarashi M, Yokoe H, Tubuki M, Tokiwa H
    • Organizer
      3rd International Conference of Drug Design 2014
    • Place of Presentation
      Oxford, UK
    • Year and Date
      2014-09-23 – 2014-09-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of Novel Multi-target Inhibitor for HA & NA of Influenza Virus2014

    • Author(s)
      Ishitsubo E, Hosozawa T, Igarashi M, Kirshner KN, Sriwilaijaroen N, Yokoe H, Tubuki M, Suzuki Y, Tokiwa H
    • Organizer
      International Symposium on Sialoglyco 2014
    • Place of Presentation
      Gold Coast, Australia
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] ニワトリのインフルエンザウイルスはフコシル化α2,3シアル酸糖鎖をレセプターとする2014

    • Author(s)
      日尾野隆大、岡松正敏、五十嵐学、西原祥子、高瀬明、迫田義博、喜田宏
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 第一原理計算によるムメフラールとインフルエンザウイルス表面糖タンパク質との理論的相互作用解析2014

    • Author(s)
      石坪江梨花、五十嵐学、Karl N. Kirshner、Nongluk Sriwilaijaroen、細沢拓未、横江弘雅、津吹政可、鈴木康夫、常盤広明
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Research-status Report
  • [Presentation] ニワトリのインフルエンザウイルスのヘマグルチニン220 ループの構造がフコース付加α2,3レセプターとの結合特異性を決定する2014

    • Author(s)
      日尾野隆大、岡松正敏、五十嵐学、西原祥子、高瀬明、迫田義博、喜田宏
    • Organizer
      第28回インフルエンザ研究者交流の会シンポジウム
    • Place of Presentation
      鳥取県鳥取市
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Research-status Report
  • [Presentation] インフルエンザウイルス蛋白質の計算科学的解析2014

    • Author(s)
      五十嵐学
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] De novo designed molecule to develop structure-based vaccine against Anthrax2013

    • Author(s)
      大西なおみ、武藤芽未、藤倉大輔、五十嵐学、東秀明
    • Organizer
      第60回毒素シンポジウム
    • Place of Presentation
      楓香荘(兵庫県宍粟市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 豚コレラウイルスの豚に対する病原性に関与するウイルス表面糖蛋白E2の機能解析2013

    • Author(s)
      田村友和、迫田義博、五十嵐学、Nicolas R、伊藤公人、岡松正敏、喜田宏
    • Organizer
      第47回日本ウイルス学会北海道支部会夏季シンポジウム
    • Place of Presentation
      ホテル北の湯(北海道奈井江町)
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規抗炭疽ワクチンの開発に向けた人工設計タンパク質の作出2013

    • Author(s)
      武藤芽未、大西なおみ、藤倉大輔、五十嵐学、東秀明
    • Organizer
      第7回細菌学若手コロッセウム
    • Place of Presentation
      広島エアポートホテル(広島県三原市)
    • Related Report
      2013 Research-status Report
  • [Presentation] De novo designed molecule to develop structure-based vaccine against Anthrax2013

    • Author(s)
      大西なおみ、武藤芽未、藤倉大輔、五十嵐学、東秀明
    • Organizer
      第12回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ダニ媒介性フラビウイルスによる中枢神経系病態におけるNS5蛋白の影響の解析2013

    • Author(s)
      好井健太朗、寸田祐嗣、五十嵐学、横澤香菜、境瑞紀、苅和宏明、Michael Holbrook、高島郁夫
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学(岐阜県岐阜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ダニ媒介性フラビウイルスによる中枢神経系病態に関わるウイルス因子の同定2013

    • Author(s)
      好井健太朗、寸田祐嗣、五十嵐学、横澤香菜、境瑞紀、苅和宏明、Michael Holbrook
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 第一原理計算を用いたインフルエンザウイルス表面糖タンパク質とマルチターゲット医薬リード天然物との高精度相互作用解析2013

    • Author(s)
      石坪江梨花、Kirshner Karl N、五十嵐学、Sriwilaijaroen Nongluk、鈴木康夫、常盤広明
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 計算科学的手法を用いたインフルエンザウイルスヘマグルチニンと亜型間交差反応性抗体との分子間相互作用の解析2013

    • Author(s)
      五十嵐学、吉田玲子、関嶋政和、常盤広明、喜田宏、伊藤公人、高田礼人
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Related Report
      2013 Research-status Report
  • [Remarks] 北海道大学人獣共通感染症リサーチセンター 国際疫学部門 メンバー紹介

    • URL

      http://www.czc.hokudai.ac.jp/epidemiol/members/igarashi/

    • Related Report
      2016 Annual Research Report 2015 Research-status Report 2014 Research-status Report
  • [Remarks] バイオインフォマティクス部門 メンバーページ

    • URL

      http://www.czc.hokudai.ac.jp/bioinform/members/igarashi/index_j.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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