| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Mucosal immunization with influenza virus vaccine confers cross-protection against infection with influenza virus antigenic variants as well as multiple subtypes of influenza A viruses. In this study, we found that many cross-reactive but non-neutralizing anti-HA IgA antibodies are produced in the upper respiratory tract of immunized mice. These anti-HA IgA antibodies showed stronger antiviral activities against influenza A viruses than IgG antibodies. Particularly, the results from this study suggest that the inhibition of virus particles release from the infected cell surface may be one of the IgA-mediated protective mechanisms important for heterosubtypic immunity.
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