| Project/Area Number |
25450420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Kotaro 帯広畜産大学, 畜産学部, 准教授 (90455709)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 病理・病態 / 牛ウイルス性下痢症ウイルス / 持続感染 / ウイルス遺伝子 / PCR / 神経疾患 / 血管 / 牛ウイルス性下痢・粘膜病 / 糸球体 / 血栓 / 病理 / 中枢神経 |
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| Outline of Final Research Achievements |
Bovine viral diarrhea virus (BVDV) infection is one of the most important causative agent for digestive tract disease. Intrauterine infection to the fetus without effective immune response causes persistent infection and this state related to various pathologic states. This research revealed the precise pathobiology of newly recognized diseases associated with BVDV persistent infection: 1) leukodystrophy characterized by severe gliosis and hypomyelinogenesis, and 2) systemic glomeruloid angiopathy characterized by intramural proliferation of vascular endothelial cells and smooth muscle cells. In the present research, we also examined whether BVDV persistent infection relate to other uncleared disease conditions, including vascular diseases with fibrinoid change which is one of the characteristic finding for BVDV infection, and central nervous system diseases. Unfortunately, however, we could not find new BVDV persistent infection-related disease.
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