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Development of vaccines against leishmaniasis using polyvalent CDV vaccine and cytokine adjuvant.

Research Project

Project/Area Number 25450421
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionThe University of Tokyo

Principal Investigator

SATO HIROKI  東京大学, 医科学研究所, 助教 (50418654)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsイヌジステンパーウイルス / リーシュマニア / 二価ワクチン / インターロイキン18 / リバースジェネティクス
Outline of Final Research Achievements

Leishmaniasis is one of the six major tropical diseases documented by WHO. Leishmaniasis is caused by infection with parasite protozoa Leishmania, and dogs harboring Leishmania act as reservoirs. There is presently no vaccine against leishmaniasis.
We generated recombinant canine distemper viruses (rCDVs) that express Leishmania antigens or Th1 cytokine, and evaluated their protective efficacy against Leishmania challenge. As a result, the cocktail of three rCDVs expressing different antigens showed significant vaccine efficiency.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 3 results)

  • [Journal Article] Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs.2015

    • Author(s)
      Miura R, Kooriyama T, Yoneda M, Takenaka A, Doki M, Goto Y, Sanjoba C, Endo Y, Fujiyuki T, Sugai A, Tsukiyama-Kohara K, Matsumoto Y, Sato H, Kai C.
    • Journal Title

      PLoS Negl Trop Dis.

      Volume: 9 Issue: 7 Pages: e0003914-e0003914

    • DOI

      10.1371/journal.pntd.0003914

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Construction of an Expression System for Bioactive IL-18 and Generation of Recombinant Canine Distemper Virus Expressing IL-182014

    • Author(s)
      Liu Y, Sato H, Hamana M, Moonan NA, Yoneda M, Xia X, Kai C.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 76 Issue: 9 Pages: 1241-1248

    • DOI

      10.1292/jvms.14-0181

    • NAID

      130004693902

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of two recent Japanese field isolates of canine distemper virus and examination of the avirulent strain utility as an attenuated vaccine.2014

    • Author(s)
      Takenaka A, Yoneda M, Seki T, Uema M, Kooriyama T, Nishi T, Fujita K, Miura R, Tsukiyama-Kohara K, Sato H, Kai C.
    • Journal Title

      Vet Microbiol

      Volume: 174(3-4) Issue: 3-4 Pages: 372-81

    • DOI

      10.1016/j.vetmic.2014.10.024

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant

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Published: 2014-07-25   Modified: 2019-07-29  

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