Development of Microminipig model of atherosclerosis for medical device development
| Project/Area Number |
25450426
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Veterinary medical science
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
谷本 昭英 鹿児島大学, 医歯学域医学系, 教授 (10217151)
三好 宣彰 鹿児島大学, 農水産獣医学域獣医学系, 教授 (80229905)
三浦 直樹 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (80508036)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IZUMI Yasukatsu 大阪市立大学, 医学(系)研究科(研究院), 准教授 (10347495)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 動脈硬化モデル動物 / ミニブタ / 高脂肪高コレステロール食 / ミニブタ動脈硬化発症モデル / 高血圧 / 病理組織学的画像解析 / 臨床画像検査 / 医療機器開発 / 病理学 / 循環器・高血圧 / 栄養学 / マイクロミニピッグ / 高脂肪・高コレステロール食 / 動脈硬化 / NOS阻害剤 / 高コレステロール血症 / エコー / アンジオテンシンII |
|---|
| Outline of Final Research Achievements |
We established a model of atherosclerosis in the Microminipig by giving animals a high fat and high cholesterol diet for 8 weeks. The aim of this study is to induce atherosclerosis which can be confirmed by a clinical imaging test for short period using the previous our model. This study added angiotensin II for 2 weeks or NOS inhibitor for 8 weeks to the above diet control. The addition of angiotensin II and NOS could induce accelerated atherosclerotic lesions of systemic aorta and arteries for while the atherosclerotic lesions (ex. intima thickening) were not recognized by carotid artery echo. Model improvement or consideration of evaluation method (ex. CAVI: Cardio Ankle Vascular Index) will be needed in the future.
|
Report
(5 results)
Research Products
(24 results)
-
[Journal Article] Microminipigs as a new experimental animal model for toxicological studies: comparative pharmacokinetics of perfluoroalkyl acids.2016
Author(s)
Guruge KS, Noguchi M, Yoshioka K, Yamazaki E, Taniyasu S, Yoshioka M, Yamanaka N, Ikezawa M, Tanimura N, Sato M, Yamashita N, Kawaguchi H.
-
Journal Title
J Appl Toxicol
Volume: 36
Issue: 1
Pages: 68-75
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
