Analysis of the mechanism of Oocyst formation: construction of newly strategy for malaria prevention

Research Project

Project/Area Number	25450430
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Veterinary medical science
Research Institution	Kitasato University
Principal Investigator	Ikadai Hiromi 北里大学, 獣医学部, 准教授 (80327460)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	マラリア原虫 / オーシスト / 遺伝子欠損 / 遺伝子欠損原虫
Outline of Final Research Achievements	Using a combination of genetic analysis and functional studies in the rodent malaria model Plasmodium berghei, we identified five oocyst capsule proteins (PbCaps) and four ookinete expression proteins of conserved Plasmodium proteins. Moreover, we report on the characterization of two PbCaps (PbCap 93 and 494). Genetic analysis indicates that the gene is essential and that two PbCaps(-) mutant parasites form oocysts in decreased numbers. Targeting of the oocyst capsule may provide a new strategy for malaria control.

Report

(4 results)