Research Project
Grant-in-Aid for Scientific Research (C)
(1) Our epidemiological study revealed that the specific antibodies against BDV were present in one fourth of cats, even in cats aged below one year. The seropositive ratio was constant, irrespective of age and sampling season. The present study suggests that additional factors are required for onset of Borna disease in naturally infected cats and that BDV is transmitted through vertical routes in cats. (2) The regulatory expression of genes related to the TGF-b family, and the role of the enhanced BMP pathway in modulating cell responses in BDV-infected glial cells, suggesting that endogenous BMP activity is responsible for the expression of IGFBP-3. (3) Corticosterone upregulates transmission efficiency of BDV in neurons and that kainic acid exposure enhances neuronal excitotoxicity induced by BDV infection.
All 2016 2015 2014 2013 Other
All Journal Article (4 results) (of which Peer Reviewed: 2 results, Acknowledgement Compliant: 3 results, Open Access: 1 results) Presentation (6 results) (of which Invited: 1 results) Remarks (2 results)
Microbes Infect.
Volume: 18 Pages: 128-136
Journal of Veterinary Medical Science
Volume: 76 Issue: 8 Pages: 1157-1160
10.1292/jvms.13-0349
130004432187
京都産業大学先端科学技術研究所所報
Volume: 13 Pages: 69-80
110009624060
京都産業大学先端技術研究所所報
Volume: 12 Pages: 93-99
http://www.kyoto-su.ac.jp/graduate/g_ls/kyoin/nishino.html
http://www.kyoto-su.ac.jp/faculty/professors/nls/nishino-yoshii.html