Investigation of pathological mechanisms for diagnostic and treatment strategy of glomerulonephropathy in dogs and cats

• Project/Area Number: 25450446
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Kagoshima University
• Principal Investigator: Yabuki Akira 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (10315400)
• Co-Investigator(Renkei-kenkyūsha): YAMATO OSAMU 鹿児島大学, 農水産獣医学域獣医学系, 教授 (80261337) ; ICHII OSAMU 北海道大学, 獣医学部, 准教授 (60547769)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 犬 / 糸球体腎症 / 免疫複合体糸球体腎炎 / 病態機序 / 糸球体腎炎 / 蛋白漏出性腎症 / 免疫組織化学 / 腎生検 / 猫 / 免疫複合体

Outline of Final Research Achievements

The aim of the present study was to clarify the pathological mechanisms of glomerulonephropathy in dogs and cats, especially in dogs. In pathologically, interstitial fibrosis was closely related with the deterioration of renal functions. Changes of several factors including carbohydrate chains, nephrin, and ghrelin were demonstrated in the cases with glomerulonephropathy, especially immune-complex mediated glomerulonephritis (ICGN). However, no common changes were detected in the course of ICGN, and this finding was thought to be reflected the complexity of pathological changes and clinical features of this disease.

Research Products

• [Journal Article] Canine IgA nephropathy: a case report (2016)
  • Author(s): Yabuki A, Shimokawa Miyama T, Kohyama M, Yamato O
  • Journal Title: Journal of Veterinary Medical Science Volume: 78 Issue: 3 Pages: 513-515
  • DOI: 10.1292/jvms.15-0161
  • NAID: 130005140908
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Change in intrarenal Ghrelin expression in immune complex-mediated glomerular disease in dogs (2016)
  • Author(s): Yabuki A, Mizukami K, Tokunaga S, Yamato O
  • Journal Title: Journal of Veterinary Medical Science Volume: 78 Issue: 1 Pages: 109-112
  • DOI: 10.1292/jvms.15-0404
  • NAID: 130005121604
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 糸球体疾患を発症した血縁の犬3例 (2016)
  • Author(s): 矢吹 映、小山 奈菜美、川畑貴裕、大和 修
  • Organizer: 平成27年度日本獣医師会獣医学術大会
  • Place of Presentation: 秋田キャッスルホテル（秋田県秋田市）
  • Year and Date: 2016-02-26
• [Presentation] 糸球体疾患を発症した血縁の犬2例 (2015)
  • Author(s): 矢吹 映、小山 奈菜美、川畑貴裕、大和 修
  • Organizer: 平成27年度獣医学術九州地区学会
  • Place of Presentation: メルパルク熊本（ 熊本県熊本市 ）
  • Year and Date: 2015-10-16
• [Presentation] 犬の免疫複合体糸球体腎炎におけるレクチン組織化学的検索 (2015)
  • Author(s): 矢吹 映、島（澤）真理子、神山萌子、大和 修
  • Organizer: 第158回日本獣医学会
  • Place of Presentation: 北里大学獣医学部（青森県十和田市）
  • Year and Date: 2015-09-07
• [Presentation] 犬の糸球体疾患における腎組織障害と臨床的病態との関連性 (2015)
  • Author(s): 矢吹 映, 櫛田和哉、神山萌子、徳永 暁, 大和 修
  • Organizer: 平成26年度 日本獣医師会獣医学術学会年次大会
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市北区駅元町）
  • Year and Date: 2015-02-13 – 2015-02-15
• [Presentation] 腎アミロードーシスの１例、腎生検による病理所見と臨床病理学的所見 (2014)
  • Author(s): 島田 大、島田のぞみ、坂本栄一、矢吹 映
  • Organizer: 第35回動物臨床医学会
  • Place of Presentation: 大阪国際会議場（大阪市北区中之島）
  • Year and Date: 2014-11-20 – 2014-11-22
• [Presentation] 犬の糸球体疾患における腎組織障害と臨床的病態との関連性 (2014)
  • Author(s): 矢吹 映、徳永 暁、大和 修
  • Organizer: 第63回九州地区獣医師大会
  • Place of Presentation: 鹿児島県民交流センター（鹿児島県鹿児島市山下町）
  • Year and Date: 2014-10-04