| Project/Area Number |
25450458
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Veterinary medical science
|
|---|
| Research Institution | Tokyo University of Agriculture (2015)
Hokkaido Research Organization (2013-2014) |
|---|
Principal Investigator |
Hirayama Hiroki 東京農業大学, 生物産業学部, 准教授 (60390861)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
FUKUDA Shigeo 北海道立総合研究機構, 畜産試験場, 主査 (00390865)
|
|---|
| Research Collaborator |
SHIRASUNA Komei 東京農業大学, 農学部, 助教
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 牛 / 分娩 / 胎盤 / 分娩誘起 / TGF-β |
|---|
| Outline of Final Research Achievements |
Mechanisms of detachment of fetal membrane after parturition in cattle are poorly un- derstood. We compared the disappearance of trophoblast binucleate cells (BNCs) and expression of transforming growth factor-beta (TGFB) in term placentomes between spontaneous and induced parturition to investigate the influences of glucocorticoids on the placental maturity.
The number of binucleated cells was lower in the spontaneous parturition (SP) group than in groups induced parturition with prostaglandin F2a (PG) or dexamethasone (DEX). mRNA levels of TGFB1, TGFBR1 and TGFBR2 in the SP group differed from PG and DEX groups. In all analyses, there was no difference between the SP group and the BET group that was induced parturition with triamcinolone acetonide and betamethasone.
Results in the BET group suggest that investigation into types, dose, and dosage schedule of glucocorticoids may facilitate placental maturation.
|
