Analysis of osmoreceptor molecules in the supraoptic nucleus of the hypothalamus
| Project/Area Number |
25450464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Naoki 鳥取大学, 農学部, 准教授 (80301951)
ASANO Atsushi 鹿児島大学, 共同獣医学部, 教授 (90312404)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 浸透圧受容 / バゾプレシン / 視索上核 / パッチクランプ / 細胞内Ca2+ / TRPV1 / 体液浸透圧 / 細胞内Ca2+濃度 / 浸透圧 / Capsaicin / GIRK / オキシトシン / RT-PCR |
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| Outline of Final Research Achievements |
The regulatory mechanism for the body fluid osmolality is known to be precise and enable to control the large volume of the body water at a level of a few percent accuracy. The osmoreceptor is the molecule to sense changes in the body osmolality and the central osmoreceptor has not been elucidated to date. The purpose of the present study was to study the molecular identity of the central osmoreceptor. Our results suggest that the central osmoreceptor may be a heterotetramer comprised of the transient receptor potential vanilloid 1 (TRPV1) and its related molecules.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Full-length transient receptor potential vanilloid 1 channels mediate calcium signals and possibly contribute to osmoreception in vasopressin neurones in the rat supraoptic nucleus.2014
Author(s)
T. Moriya, R. Shibazaki, T. Kayano, N. Takebuchi, M. Ichimura, N. Kitamura, A. Asano, Y. Z. Hosaka, O. Forostyak, A. Verkhratsky, G. Dayanithi, I. Shibuya.
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Journal Title
Cell Calcium
Volume: 57
Pages: 25-37
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] RT-PCR and Ca2+ imaging analyses of osmoreceptor molecules in the rat SON.2014
Author(s)
Taiki Moriya, Rina Shibasaki, Tomohiko Kayano, Nami Takebuchi, Momoko Ichimura, Naoki Kitamura, Atsushi Asano, Yoshinao Z. Hosaka, Oksana Forostyak, Alexej Verkhratsky, Govindan Dayanithi, Izumi Shibuya.
Organizer
Neuroscience 2014
Place of Presentation
Washington DC, USA
Year and Date
2014-11-15 – 2014-11-19
Related Report
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