Immunological study on bovine leukemia virus infection
| Project/Area Number |
25450468
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
Norimine Junzo 宮崎大学, 産業動物リサーチセンター, 教授 (30627667)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 牛白血病 / 牛白血病ウイルス / 抵抗性遺伝子 / テトラマー / CD4T細胞 / MHC class II / ウイルス量 / 免疫防御 / 抵抗性 / DRB3 |
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| Outline of Final Research Achievements |
Because approximately 70% of cattle infected with bovine leukemia virus remain healthy for their lives, it has been thought that there exist resistant genes exist against this disease. This study confirmed one of the resistant genes in both dairy and Japanese black cattle. The field study has demonstrated that cattle with the resistant gene could be utilized as a protectiveon wall for the infection. The investigator also developed the first immunological analytic tool, a bovine immunological “tetramer”, and is currently studying the resistant mechanisms using the tool.
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Report
(4 results)
Research Products
(8 results)
