The role and networks of immune and nonimmune cells in the small intestine in the early stage of gastrointestinal parasite infection.
| Project/Area Number |
25450469
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Miyagi University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAI TOSHIYUKI 東北大学, 加齢医学研究所, 教授 (20187917)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 線虫 / 2型サイトカイン / 樹状細胞 / 小腸 / T細胞 / サイトカイン / メモリー応答 / 自然リンパ球 / 寄生虫 / 腸間膜リンパ節 / 消化管上皮 / Th2 |
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| Outline of Final Research Achievements |
The coordinated actions of lymphocytes, innate immune cells, epithelium, and smooth muscles can play an important role in host intestinal immune function and homeostasis. We investigated type2 immune responses in early stage against nematode parasite in the murine intestine. The results suggested that innate immune cells initiate production of type2 cytokines, communicate with other immune cells including T cells and mediate adaptive pathogen-specific immune responses to eliminate pathogens. INFgamma; might regulate the termination of innate immune responses in the early stage. While, Th2 play mainly in memory responses against re-infection of nematode parasite.
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Report
(4 results)
Research Products
(6 results)
