Understanding favorable trait of domestic animal and chronic disease of human based on epigenome engineering
| Project/Area Number |
25450472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Meiji University |
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Principal Investigator |
Ohgane Jun 明治大学, 農学部, 准教授 (50313078)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | エピジェネティクス / エピゲノム改変 / 非コード（nc）RNA / 食肉形質 / 生活習慣病 / 非コード(nc）RNA / 非コードRNA |
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| Outline of Final Research Achievements |
DNA methylation analysis based on allelic methylation status has been established in the present project, and this enabled us to estimate ratios of particular cell types in tissues containing multiple cell types and heterogenous cultured cell populations. Moreover, a screening method to identify long non-coding RNAs related to epigenetic regulation of nearby genes has been established. Therefore, basic technology to perform epigenome engineering established in this project.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells.2015
Author(s)
Arai Y, Hayakawa K, Arai D, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R, Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Hirosawa M, Shiota K, Ohgane J.
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Journal Title
Biomed Res Int.
Volume: 2015
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells2015
Author(s)
Arai Y, Hayakawa K, Arai D, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R,Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Hirosawa M, Shiota K, Ohgane J
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Journal Title
BioMed Res Int
Volume: in press
Related Report
Peer Reviewed / Open Access
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[Journal Article] DNA methylation profiles provide a viable index for porcine pluripotent stem cells.2013
Author(s)
Arai Y, Ohgane J, Fujishiro SH, Nakano K, Matsunari H, Watanabe M, Umeyama K, Azuma D, Uchida N, Sakamoto N, Makino T, Yagi S, Shiota K, Hanazono Y, Nagashima H.
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Journal Title
Genesis
Volume: 51
Issue: 11
Pages: 763-776
DOI
Related Report
Peer Reviewed
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[Presentation] Evaluation of porcine induced pluripotent stem cells based on the DNA methylation profile of mouse embryonic stem cell-specific hypomethylated loci.
Author(s)
Arai Y, Ohgane J, Fujishiro S, Nakano K, Matsunari H, Watanabe M, Umeyama K, Azuma D, Uchida N, Sakamoto N, Makino T, Yagi S, Shiota K, Hanazono Y, Nagashima H
Organizer
第36回日本分子生物学会
Place of Presentation
兵庫
Related Report
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