| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Our proteomic analysis of rodent cytoplasmic ribosomes revealed their structural heterogeneity. This analysis identified a zinc finger protein, Lyar, in testicular ribosomes. Lyar was suggested to be included in the 60S large subunit, but not in polysomes, by ultracentrifugation of testicular ribosomes. Furthermore, translation was increased by Lyar in vitro, pointing out the involvement of this protein in translation. Overall, our data in this study (including unpublished ones) are expected to make a connection between ribosome heterogeneity and translational control.
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