| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Alarmins are endogeneous molecules that act as danger signals to promote inflammation or innate immune response. Since they are mainly secreted from macrophage-related cells, we performed P2X7 receptor-secretome analysis using ATP-stimulated mouse microglial cells, known as brain macrophages, to search for novel alarmins. We have identified 640 different proteins as candidate molecules that may act as alarmins. Among them, we demonstrated the unconventional secretion pathway and innate immunomodulatory functions of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in microglial cells. The findings suggest that GAPDH secreted from macrophages may act as a mediator of innate immune system.
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