Development of Unprecedented Catalytic Carbocyanation
| Project/Area Number |
25460004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
Arai Shigeru 千葉大学, 薬学研究科(研究院), 准教授 (20285224)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ニッケル / 遷移金属触媒 / シアノ化 / 環化 / アルキン / ヒドロシアノ化 / ヒドロシアアノ化 / ニッケル触媒 / アレン / ヒドロアシル化 / コバルト触媒 / アルカロイド合成 / シクロプロパン / 環化反応 / ヘテロ環 |
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| Outline of Final Research Achievements |
We have developed the discrimination of CC multiple bonds through Ni-catalyzed hydrocyanation and established regio- and stereoselective cyanation of alkynes, allenes, and enynes. These substrates are easily transformed to the corresponding carbonitriles and allene system is particularly effective to obtain a single product through this methodology. Allenyl cyclopropane are also effectively converted to the secondary carbonitriles as a sole product via CC sigma bond cleavage of cyclopropane and further application for the synthesis \of natural products are currently undergoing.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Total synthesis of schizocommunin and revision of its structure2013
Author(s)
Uehata, K., Kimura, N., Hasegawa, K., Arai, S., Nishida, M., Hosoe, T., Kawai, K.-I., Nishida, A.
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Journal Title
Journal of Natural Products
Volume: 76
Issue: 11
Pages: 2034-2039
DOI
Related Report
Peer Reviewed
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