| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We have developed the discrimination of CC multiple bonds through Ni-catalyzed hydrocyanation and established regio- and stereoselective cyanation of alkynes, allenes, and enynes. These substrates are easily transformed to the corresponding carbonitriles and allene system is particularly effective to obtain a single product through this methodology. Allenyl cyclopropane are also effectively converted to the secondary carbonitriles as a sole product via CC sigma bond cleavage of cyclopropane and further application for the synthesis \of natural products are currently undergoing.
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