| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Because of the aging society, the discovery of new remedies for memory disorder (or Alzheimer disease) is urgent business in Japan.Some Lycopodium alkaloids are known to have acetylcholine esterase (AChE) inhibitory activity. This research was aimed for the discovery of Lycopodium alkaloids which have strong activity against AChE by separation from Lycopodium plants and total synthesis from commercially available reagents.
As a result, we have isolated many Lycopodium alkaloids from L. carinata and L. nummulariforium, distributed in Thailand, and elucidated their structures by spectroscopic analyses and chemical conversions. Furthermore, we have achieved the total syntheses of natural Lycopodium alkaloids utilizing our original strategy. The shortest total synthesis of lycodine was accomplished by a strategy featuring the one-pot construction of a tetra cyclic lycodine skeleton from a linear precursor, which was inspired by the biosynthetic consideration of Lycopodium alkaloids.
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