| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
I developed the catalytic and enantioselective Diels-Alder reaction using heterocycle-fused siloxydienes. This reaction was promoted by novel chiral holmium catalyst. The adducts are optically active multi-cyclic compounds, and they could be used as synthetic intermediates of biologically active compounds. For instance, I achieved the enantioselective total synthesis of Minovincine from the optically active hydrocarbazole derived from the Diels-Alder reaction of indole-fused diene.
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