Catalytic and Enantioselective Construction of Multi-Substituted Cyclohexane-Fused Heterocycles Having Chiral Tetrasubstituted Carbon
| Project/Area Number |
25460006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
Harada Shinji 千葉大学, 薬学研究科(研究院), 助教 (10451759)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 合成化学 / 不斉触媒 / ヒドロカルバゾール / ホルミウム / 多環性骨格構築 / 全合成 / 不斉四級炭素 / スカンジウム |
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| Outline of Final Research Achievements |
I developed the catalytic and enantioselective Diels-Alder reaction using heterocycle-fused siloxydienes. This reaction was promoted by novel chiral holmium catalyst. The adducts are optically active multi-cyclic compounds, and they could be used as synthetic intermediates of biologically active compounds. For instance, I achieved the enantioselective total synthesis of Minovincine from the optically active hydrocarbazole derived from the Diels-Alder reaction of indole-fused diene.
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Report
(4 results)
Research Products
(34 results)
