| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this research project, we have established the strategy for the divergent synthesis of the highly oxygenated steroid compounds. The stereocontrolled synthesis of the core system of the steroid has been developed by the convergent radical coupling of the diverse AB-rings and the D-ring and the following stereoselective intramolecular aldol reaction. Based on the developed method, the total synthesis of complex natural product ouabagenin has been achieved. Furthermore, the intermediate towards toosendanine has been synthesized.
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