Development of the stereocontrolled synthesis of the highly oxygenated steroids

• Project/Area Number: 25460007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: Urabe Daisuke 東京大学, 薬学研究科(研究院), 講師 (80503515)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 有機合成化学 / 天然物 / 生物活性物質 / 全合成 / 立体選択性 / ステロイド / 立体化学 / 立体選択的変換反応 / アルドール反応 / グリコシル化 / 生理活性物質 / ラジカル反応 / カップリング

Outline of Final Research Achievements

In this research project, we have established the strategy for the divergent synthesis of the highly oxygenated steroid compounds. The stereocontrolled synthesis of the core system of the steroid has been developed by the convergent radical coupling of the diverse AB-rings and the D-ring and the following stereoselective intramolecular aldol reaction. Based on the developed method, the total synthesis of complex natural product ouabagenin has been achieved. Furthermore, the intermediate towards toosendanine has been synthesized.

Research Products

• [Journal Article] Symmetry-Driven Strategy for the Assembly of the Core Tetracycle of (+)-Ryanodine: Synthetic Utility of a Cobalt-Catalyzed Olefin Oxidation and α-Alkoxy Bridgehead Radical Reaction (2016)
  • Author(s): M. Nagatomo, K. Hagiwara, K. Masuda, M. Koshimizu, T. Kawamata, Y. Matsui, D. Urabe, M. Inoue
  • Journal Title: Chem. Eur. J. Volume: 22 Issue: 1 Pages: 222-229
  • DOI: 10.1002/chem.201503640
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Total Synthesis of Crotophorbolone (2015)
  • Author(s): Asaba, T.; Katoh, Y.; Urabe, D.; Inoue, M.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 54 Issue: 48 Pages: 14457-14461
  • DOI: 10.1002/anie.201509160
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Total synthesis of four stereoisomers of (5Z,8Z,10E,14Z)-12-hydroxy-17,18-epoxy-5,8,10,14-eicosatetraenoic acid and their anti-Inflammatory activities (2015)
  • Author(s): Goto, T.; Urabe, D.; Isobe, Y.; Arita, M.; Inoue, M.
  • Journal Title: Tetrahedron Volume: 71 Issue: 43 Pages: 8320-8332
  • DOI: 10.1016/j.tet.2015.08.047
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Total synthesis of four stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-dihydroxy-4,7,10,12,16,18-docosahexaenoic acid and their anti-inflammatory activities. (2015)
  • Author(s): Goto T, Urabe D, Masuda K, Isobe Y, Arita M, Inoue M.
  • Journal Title: J Org Chem Volume: 80 Issue: 15 Pages: 7713-7726
  • DOI: 10.1021/acs.joc.5b01461
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Convergent Total Synthesis of Ouabagenin (2015)
  • Author(s): Ken Mukai, Satoshi Kasuya, Yuki Nakagawa, Daisuke Urabe, Masayuki Inoue
  • Journal Title: Chemical Science Volume: 印刷中 Issue: 6 Pages: 3383-3387
  • DOI: 10.1039/c5sc00212e
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] N-(2,3,4,5,6-Pentafluorophenyl)maleimide as a Powerful Dienophile in Dearomatizing Diels-Alder Reactions (2015)
  • Author(s): K. Hagiwara, M. Iwatsu, D. Urabe, M. Inoue
  • Journal Title: Heterocycles Volume: 90 Issue: 1 Pages: 659-672
  • DOI: 10.3987/com-14-s(k)23
  • Peer Reviewed
• [Journal Article] Asymmetric Total Synthesis of (−)-4-Hydroxyzinowol, a Highly Oxygenated Dihydro-β-Agarofuran (2015)
  • Author(s): Urabe, D.; Todoroki, H.; Inoue, M.
  • Journal Title: Journal of Synthetic Organic Chemistry, Japan Volume: 73 Issue: 11 Pages: 1081-1091
  • DOI: 10.5059/yukigoseikyokaishi.73.1081
  • NAID: 130005113516
  • ISSN: 0037-9980, 1883-6526
  • Peer Reviewed
• [Journal Article] Radical-Mediated Three-Component Reaction: A Study toward the Total Synthesis of Resiniferatoxin (2015)
  • Author(s): Urabe, D.
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 63 Issue: 8 Pages: 565-572
  • DOI: 10.1248/cpb.c15-00373
  • NAID: 130005090108
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Multifunctionality of the N-Trichloroacetyl Group Developed in the Synthesis of Tetrodotoxin, a Puffer Fish Toxin (2015)
  • Author(s): Toshio Nishikawa, Daisuke Urabe, Masaatsu Adachi, Minoru Isobe
  • Journal Title: Synlett Volume: 26 Issue: 14 Pages: 1930-1939
  • DOI: 10.1055/s-0034-1380781
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Convergent strategies in total syntheses of complex terpenoids (2015)
  • Author(s): Urabe, D.; Asaba, T.; Inoue, M.
  • Journal Title: Chem. Rev. Volume: 115 Issue: 17 Pages: 9207-9231
  • DOI: 10.1021/cr500716f
  • Peer Reviewed
• [Journal Article] 合成化学者の特権!? 新規抗炎症性脂質メディエーターの発見 (2015)
  • Author(s): 占部大介
  • Journal Title: ファルマシア Volume: 51 Pages: 800-800
  • NAID: 130007448246
  • Peer Reviewed
• [Journal Article] Total Synthesis of (-)-4-Hydroxyzinowol (2014)
  • Author(s): H. Todoroki, M. Iwatsu, D. Urabe, M. Inoue
  • Journal Title: J. Org. Chem. Volume: 79 Issue: 18 Pages: 8835-8849
  • DOI: 10.1021/jo501666x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Total Synthesis of Ryanodol (2014)
  • Author(s): Masanori Nagatomo, Masaki Koshimizu, Kengo Masuda, Toshiki Tabuchi, Daisuke Urabe, Masayuki Inoue
  • Journal Title: Journal of the American Chemical Society Volume: 136 Issue: 16 Pages: 5916-5919
  • DOI: 10.1021/ja502770n
  • Peer Reviewed
• [Journal Article] Studies in symmetry-driven synthesis of ryanodol: application of nucleophilic alkynylation for regio- and stereoselective desymmetrization (2014)
  • Author(s): K. Hagiwara, D. Urabe, M. Inoue
  • Journal Title: Tetrahedron Lett. Volume: 55 Issue: 28 Pages: 3817-3819
  • DOI: 10.1016/j.tetlet.2014.05.075
  • Peer Reviewed
• [Journal Article] Identification of 14,20-dihydroxy-docosahexaenoic acid as a novel anti-inflammatory metabolite (2014)
  • Author(s): Yoshiyuki Yokokura, Yosuke Isobe, Shinnosuke Matsueda, Ryo Iwamoto, Tomomi Goto, Takeshi Yoshioka, Daisuke Urabe, Masayuki Inoue, Hiroyuki Arai and Makoto Arita
  • Journal Title: the journal of biochemistry Volume: 156 Issue: 6 Pages: 315-321
  • DOI: 10.1093/jb/mvu044
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] レペニンの全合成 (2014)
  • Author(s): 占部大介
  • Journal Title: 月刊化学 Volume: 69 Pages: 61-62
• [Journal Article] Eicosapentaenoic acid is converted via omega-3 epoxygenation to anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid. (2013)
  • Author(s): Kubota T, Arita M, Isobe Y, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H
  • Journal Title: FASEB J. Volume: 28 Issue: 2 Pages: 586-593
  • DOI: 10.1096/fj.13-236224
  • Peer Reviewed / Open Access
• [Journal Article] Et3B‐Mediated Radical-Polar Crossover Reaction for Single-Step Coupling of O,Te-Acetal, α,β-Unsaturated Ketones, and Aldehydes/Ketones (2013)
  • Author(s): Kamimura, D.; Urabe, D.; Nagatomo, M.; Inoue, M.
  • Journal Title: Organic Letters Volume: 15 Issue: 19 Pages: 5122-5125
  • DOI: 10.1021/ol402563v
  • Peer Reviewed
• [Journal Article] Preparation and palladium-mediated cross-coupling of --benzoyloxyalkylzinc bromides (2013)
  • Author(s): Sakata, K.; Urabe, D.; Inoue, M
  • Journal Title: Tetrahedron Letters Volume: (in press) Issue: 32 Pages: 4189-4192
  • DOI: 10.1016/j.tetlet.2013.05.114
  • Peer Reviewed
• [Journal Article] Concise Synthesis of the Multiply Oxygenated ABC-Ring System of the Dihydro-β-agarofurans (2013)
  • Author(s): Ishiyama, T.; Urabe, D.; Fujisawa, H.; Inoue, M.
  • Journal Title: Organic Letters Volume: 15 Issue: 17 Pages: 4488-4491
  • DOI: 10.1021/ol402038b
  • Peer Reviewed
• [Journal Article] A convergent total synthesis of19-hydroxysarmentogenin. (2013)
  • Author(s): Mukai, K.; Urabe, D.; Kasuya, S.; Aoki, N.; Inoue, M
  • Journal Title: Angewandte Chemie International Edition Volume: 52 Issue: 20 Pages: 5300-5304
  • DOI: 10.1002/anie.201302067
  • Peer Reviewed
• [Journal Article] A radical-based approach for the construction of the tetracyclic structure of resiniferatoxin (2013)
  • Author(s): Murai, K.; Katoh, S.; Urabe, D.; Inoue, M
  • Journal Title: Chemical Science Volume: 4 Issue: 6 Pages: 2364-2368
  • DOI: 10.1039/c3sc50329a
  • Peer Reviewed
• [Journal Article] Asymmetric synthesis of a highly functionalized bicyclo[3.2.2]nonene derivative. (2013)
  • Author(s): Tabuchi, T.; Urabe, D.; Inoue, M.
  • Journal Title: Beilstein Journal of Organic Chemistry Volume: 9 Pages: 655-663
  • DOI: 10.3762/bjoc.9.74
  • Peer Reviewed
• [Journal Article] Symmetry-driven synthesis of 9-demethyl-10,15-dideoxyryanodol. (2013)
  • Author(s): Urabe, D.; Nagatomo, M.; Hagiwara, K.; Masuda, K.; Inoue, M.
  • Journal Title: Chemical Science Volume: 4 Issue: 4 Pages: 1615-1619
  • DOI: 10.1039/c3sc00023k
  • Peer Reviewed
• [Journal Article] Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3 (2013)
  • Author(s): Y Isobe, M. Arita, R. Iwamoto, D. Urabe, H. Todoroki, K. Masuda, M. Inoue and H. Arai
  • Journal Title: The Journal of Biochemistry Volume: 153 Issue: 4 Pages: 355-360
  • DOI: 10.1093/jb/mvs151
  • Peer Reviewed
• [Presentation] ラジカル反応を基盤としたチグリアン・ダフナンジテルペン類の合成戦略 (2016)
  • Author(s): 占部大介
  • Organizer: 日本薬学会第136年会シンポジウム 天然物ケミカルバイオロジー(4)：天然物合成とケミカルバイオロジー
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-03-29
  • Invited
• [Presentation] タラチサミンの合成研究 (2016)
  • Author(s): 鎌倉大貴、轟木秀憲、占部大介、井上将行
  • Organizer: 日本薬学会 第136年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-03-26
• [Presentation] 高酸化度アガロフラン型セスキテルペンの全合成研究 (2016)
  • Author(s): 藤澤博基、占部大介、井上将行
  • Organizer: 日本薬学会 第136年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-03-26
• [Presentation] ラジカル-極性交差反応を鍵としたC19ジテルペンアルカロイドの合成研究 (2016)
  • Author(s): 皆川功亮、占部大介、井上将行
  • Organizer: 日本薬学会 第136年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-03-26
• [Presentation] チグリアン・ダフナンジテルペンの網羅的全合成研究 (2016)
  • Author(s): 浅羽太郎、占部大介、井上将行
  • Organizer: 日本薬学会 第136年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-03-26
• [Presentation] Unified total synthesis of oxygenated cardenolides (2015)
  • Author(s): Urabe, D.; Inoue, M.
  • Organizer: PACIFICEHM2015
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Synthetic Study of Puberuline C (2015)
  • Author(s): Hagiwara, K.; Tabuchi, T.; Urabe, D.; Inoue, M.
  • Organizer: Cambridge-Utokyo joint symposium
  • Place of Presentation: Cambridge, England
  • Year and Date: 2015-11-23
  • Int'l Joint Research
• [Presentation] Total Synthesis of Crotophorbolone (2015)
  • Author(s): Urabe, D.; Inoue, M.
  • Organizer: the 15th Tateshina Conference on Organic Chemistry
  • Place of Presentation: Chino, Japan
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Synthetic Study of Batrachotoxin (2015)
  • Author(s): Sakata, K.; Wang, Y.; Urabe, D.; Inoue, M.
  • Organizer: ICCEOCA-10
  • Place of Presentation: Kaohsiung, Taiwan
  • Year and Date: 2015-11-02
  • Int'l Joint Research
• [Presentation] Synthetic Study of Batrachotoxin (2015)
  • Author(s): Sakata, K.; Wang, Y.; Urabe, D.; Inoue, M.
  • Organizer: Junior ICCEOCA-5
  • Place of Presentation: Taipei, China
  • Year and Date: 2015-10-30
  • Int'l Joint Research
• [Presentation] Synthetic Study of Highly Oxygenated Agarofuran Sesquiterpenoid (2015)
  • Author(s): Fujisawa, H.; Ishiyama, T.; Urabe, D.; Inoue, M.
  • Organizer: LMU-UTOKYO SYMPOSIUM 2015
  • Place of Presentation: Munich, German
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] レジニフェラトキシンの全合成研究 (2015)
  • Author(s): 橋本 哲、加藤駿一郎、村井耕一、占部大介、井上将行
  • Organizer: 第41回反応と合成の進歩シンポジウム
  • Place of Presentation: 近畿大学、東大阪
  • Year and Date: 2015-10-26
• [Presentation] 高酸化度アガロフラン型セスキテルペンの全合成研究 (2015)
  • Author(s): 藤澤博基、石山備凡、占部大介、井上将行
  • Organizer: 第32回有機合成化学セミナー
  • Place of Presentation: ニューウェルシティ湯河原、熱海
  • Year and Date: 2015-09-15
• [Presentation] 抗炎症性脂質メディエーターの全合成 (2015)
  • Author(s): 占部大介,
  • Organizer: 新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」地区ミニシンポジウム・仙台「ケミカルバイオロジーにおける天然物」
  • Place of Presentation: 東北大学、仙台
  • Year and Date: 2015-06-30
  • Invited
• [Presentation] チグリアン/ダフナンジテルペン類の合成戦略：クロトホルボロンの全合成 (2015)
  • Author(s): 占部大介
  • Organizer: 新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」第8回公開シンポジウム
  • Place of Presentation: 東北大学、仙台
  • Year and Date: 2015-06-08
• [Presentation] Synthetic Study of Resiniferatoxin (2015)
  • Author(s): Kato, S.; Murai, K.; Urabe, D.; Inoue, M.
  • Organizer: RSC Organic Chemistry Symposia
  • Place of Presentation: 東京大学、東京
  • Year and Date: 2015-06-03
  • Int'l Joint Research
• [Presentation] プベルリンCの全合成研究 (2015)
  • Author(s): 萩原浩一、田渕俊樹、占部大介、井上将行
  • Organizer: 第13回次世代を担う有機化学シンポジウム
  • Place of Presentation: 立命館大学、大津
  • Year and Date: 2015-05-22
• [Presentation] 橋頭位ラジカルを用いたC19ジテルペンアルカロイドの合成研究 (2015)
  • Author(s): 皆川功亮、山下智也、田渕俊樹、占部大介、井上将行
  • Organizer: 第69回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 横浜国立大学、横浜
  • Year and Date: 2015-05-16
• [Presentation] ラジカル反応を基盤とした複雑天然物の全合成研究 (2015)
  • Author(s): 占部大介
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 兵庫
  • Year and Date: 2015-03-25 – 2015-03-28
  • Invited
• [Presentation] プベルリンCの合成研究 (2015)
  • Author(s): 萩原浩一、田渕俊樹、占部大介、井上将行
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 兵庫
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] タラチサミンの全合成研究 (2015)
  • Author(s): 轟木秀憲、鎌倉大貴、占部大介、井上将行
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 兵庫
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] レジニフェラトキシンの全合成研究 (2015)
  • Author(s): 橋本哲、加藤駿一郎、村井耕一、占部大介、井上将行
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 兵庫
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 高酸化度アガロフランセスキテルペンの全合成研究 (2015)
  • Author(s): 藤澤博基、石山備凡、占部大介、井上将行
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 兵庫
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] Total synthesis of crotophorbolone (2014)
  • Author(s): Taro Asaba, Yuki Katoh, Daisuke Urabe, Masayuki Inoue
  • Organizer: JICCEOCA-4 and ICCEOCA-9/NICCEOCA-5
  • Place of Presentation: bangkok, thailand/Kuala Lumpur, Malaysia
  • Year and Date: 2014-11-25 – 2014-12-08
• [Presentation] クロトホルボロンの全合成 (2014)
  • Author(s): 浅羽太郎、嘉藤裕樹、占部大介、井上将行
  • Organizer: 第40回反応と合成の進歩シンポジウム
  • Place of Presentation: 宮城
  • Year and Date: 2014-11-10 – 2014-11-11
• [Presentation] 高酸化度アガロフラン型セスキテルペンの全合成研究 (2014)
  • Author(s): 藤澤博基、石山備凡、占部大介、井上将行
  • Organizer: 第106回有機合成シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2014-11-06 – 2014-11-07
• [Presentation] A Unified Approach to the Cardenolides and Bufadienolides: Total Synthesis of Ouabagenin (2014)
  • Author(s): Daisuke Urabe
  • Organizer: The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
  • Place of Presentation: Osaka
  • Year and Date: 2014-10-28 – 2014-10-29
• [Presentation] (+)-リアノジンの不斉全合成 (2014)
  • Author(s): 枡田健吾、長友優典、小清水正樹、萩原幸司、田渕俊樹、占部大介、井上将行
  • Organizer: 第56回天然有機化合物討論会
  • Place of Presentation: 高知
  • Year and Date: 2014-10-15 – 2014-10-17
• [Presentation] 橋頭位ラジカルを用いた高酸化度テルぺノイドの全合成研究 (2014)
  • Author(s): 占部大介
  • Organizer: 明治薬科大学
  • Place of Presentation: 東京
  • Year and Date: 2014-09-26
  • Invited
• [Presentation] リアノドールの全合成 (2014)
  • Author(s): 小清水正樹、長友優典、枡田健吾、萩原幸司、田渕俊樹，占部大介、井上将行
  • Organizer: 第31回有機合成化学セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] 橋頭位ラジカルを用いた高酸化度テルぺノイドの全合成研究 (2014)
  • Author(s): 占部大介
  • Organizer: 第49回天然物化学談話会
  • Place of Presentation: 岡山
  • Year and Date: 2014-07-02 – 2014-07-04
  • Invited
• [Presentation] プベルリンCの合成研究 (2014)
  • Author(s): 萩原浩一、田渕俊樹、占部大介、井上将行
  • Organizer: 第105回有機合成シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2014-06-10 – 2014-06-11
• [Presentation] リアノドールの全合成 (2014)
  • Author(s): 小清水正樹、長友優典，枡田健吾、田渕俊樹，占部大介，井上将行
  • Organizer: 第12回次世代を担う有機化学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2014-05-23 – 2014-05-24
• [Presentation] Total Synthesis of 19-Hydroxysarmentogenin (2014)
  • Author(s): Daisuke Urabe, Masayuki Inoue
  • Organizer: International Startup Symposium of Cutting-Edge Organic Chemistry in Asia (III)
  • Place of Presentation: Hsinchu, Taiwan
  • Year and Date: 2014-04-19 – 2014-04-22
  • Invited
• [Presentation] ウアバゲニンの全合成 (2014)
  • Author(s): 占部大介
  • Organizer: 日本薬学会第134年会シンポジウム有機合成の若い力
  • Place of Presentation: 熊本県、熊本市
  • Invited
• [Presentation] クロトホルボロンの全合成研究 (2014)
  • Author(s): 浅羽太郎、嘉藤裕樹、占部大介、井上将行
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本県、熊本市
• [Presentation] バトラコトキシンの全合成研究 (2014)
  • Author(s): 坂田光命、占部大介、井上将行
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本県、熊本市
• [Presentation] プベルリンCの合成研究 (2014)
  • Author(s): 萩原浩一、田渕俊樹、占部大介、井上将行
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本県、熊本市
• [Presentation] レジニフェラトキシンの全合成研究 (2014)
  • Author(s): 加藤駿一郎、村井耕一、占部大介、井上将行
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本県、熊本市
• [Presentation] ラジカル反応を鍵とした高酸化度テルペノイドの全合成研究 (2013)
  • Author(s): 占部大介
  • Organizer: 第1回慶應有機化学若手シンポジウム
  • Place of Presentation: 神奈川県、横浜市
  • Invited
• [Presentation] セラングリンの合成研究 (2013)
  • Author(s): 藤澤博基、石山備凡、占部大介、井上将行
  • Organizer: 第57回日本薬学会関東支部大会
  • Place of Presentation: 東京都、板橋区
• [Presentation] 立体選択的な高酸化度ステロイド骨格構築法の開発 (2013)
  • Author(s): 中川雄喜、青木直人、占部大介、井上将行
  • Organizer: 第65回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 新潟県、新潟市
• [Presentation] Synthetic study of 4-hydroxyzinowol (2013)
  • Author(s): Todoroki, H.; Iwatsu, M.; Masuda, K.; Urabe, D.; Inoue, M.
  • Organizer: 3rd Junior International Conference on Cutting-Edge Organic Chemistry in Asia
  • Place of Presentation: 千葉県、千葉市
• [Presentation] Synthetic study of 4-hydroxyzinowol (2013)
  • Author(s): Todoroki, H.; Iwatsu, M.; Masuda, K.; Urabe, D.; Inoue, M.
  • Organizer: The 8th International Conference on Cutting-Edge Organic Chemistry in Asia and The 4th New Phase International Conference on Cutting-Edge Organic Chemistry in Asia
  • Place of Presentation: 大阪府、大阪市
• [Presentation] 4-ヒドロキシジノウォールの合成研究 (2013)
  • Author(s): 轟木秀憲、岩津理史、枡田健吾、占部大介、井上将行
  • Organizer: 第55回天然有機化合物討論会
  • Place of Presentation: 京都府、京都市
• [Presentation] タラチサミンの全合成研究 (2013)
  • Author(s): 田渕俊樹、占部大介、井上将行
  • Organizer: 第39回反応と合成の進歩シンポジウム
  • Place of Presentation: 福岡県、福岡市
• [Book] Strategy and Tactics in Organic Synthesis Vol.9 (2013)
  • Author(s): Inoue, M.; Urabe, D.
  • Total Pages: 322
  • Publisher: elsevier
• [Remarks] 東京大学大学院薬学系研究科有機反応化学教室
  • URL: http://www.f.u-tokyo.ac.jp/~inoue/
• [Remarks] 東京大学大学院薬学系研究科有機反応化学教室 Inoue Research Group
  • URL: http://www.f.u-tokyo.ac.jp/~inoue/