Drug-oriented Catalytic Oxidation Targeting Remote sp3 C-H Bonds
| Project/Area Number |
25460008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Oisaki Kounosuke 東京大学, 大学院薬学系研究科(薬学部), 講師 (00583999)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | C-H活性化 / 酸素酸化 / 配向活性化基 / 分子認識 / ラジカル / 有機触媒 / 酸化 / 酸素 |
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| Outline of Final Research Achievements |
We worked on the development of a regioselective remote C(sp3)-H aerobic oxidation starting from model system with use of covalently bound N-oxyl radical directing activator. We found conditions for selective C-H oxidation of aliphatic alcohol substrate. The results were published as two original papers. Subsequently, We investigated regioselective catalytic aerobic C-H oxidation. After synthesizing and utilizing a novel N-oxyl radical organocatalyst having a trifluoromethyl ketone group as a molecular recognition site, we found a regioselective C-H oxidation with moderate selectivity. We will continue to optimize the catalyst structure for further improvement of selectivity.
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Report
(5 results)
Research Products
(105 results)
