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Drug-oriented Catalytic Oxidation Targeting Remote sp3 C-H Bonds

Research Project

Project/Area Number 25460008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Chemical pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

Oisaki Kounosuke  東京大学, 大学院薬学系研究科(薬学部), 講師 (00583999)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsC-H活性化 / 酸素酸化 / 配向活性化基 / 分子認識 / ラジカル / 有機触媒 / 酸化 / 酸素
Outline of Final Research Achievements

We worked on the development of a regioselective remote C(sp3)-H aerobic oxidation starting from model system with use of covalently bound N-oxyl radical directing activator. We found conditions for selective C-H oxidation of aliphatic alcohol substrate. The results were published as two original papers. Subsequently, We investigated regioselective catalytic aerobic C-H oxidation. After synthesizing and utilizing a novel N-oxyl radical organocatalyst having a trifluoromethyl ketone group as a molecular recognition site, we found a regioselective C-H oxidation with moderate selectivity. We will continue to optimize the catalyst structure for further improvement of selectivity.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (105 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (18 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 18 results,  Acknowledgement Compliant: 10 results,  Open Access: 3 results) Presentation (78 results) (of which Int'l Joint Research: 7 results,  Invited: 7 results) Remarks (7 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Ligand-free, copper-catalyzed aerobic benzylic sp3 C-H oxygenation2017

    • Author(s)
      Hirotaka Tanaka, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Synlett

      Volume: 28 Issue: 13 Pages: 1576-1580

    • DOI

      10.1055/s-0036-1588969

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Directing activator-assisted regio- and oxidation state-selective aerobic oxidation of secondary C(sp3)-H bonds in aliphatic alcohols2016

    • Author(s)
      Jizhi Ni, Jun Ozawa, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Organic Biomolecular Chemistry

      Volume: 14 Issue: 19 Pages: 4378-4381

    • DOI

      10.1039/c6ob00678g

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Enhanced Structural Variety of Nonplanar <i>N</i>-Oxyl Radical Catalysts and Their Application to the Aerobic Oxidation of Benzylic C–H Bonds2016

    • Author(s)
      Yoichi Kadoh, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 7 Pages: 737-753

    • DOI

      10.1248/cpb.c16-00083

    • NAID

      130005160056

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Switchable photooxygenation catalysts that sense higher-order amyloid structures.2016

    • Author(s)
      Atsuhiko Taniguchi, Yusuke Shimizu, Kounosuke Oisaki, Youhei Sohma, Motomu Kanai
    • Journal Title

      Nature Chemistry

      Volume: 8 Issue: 10 Pages: 974-982

    • DOI

      10.1038/nchem.2550

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transition metal-free tryptophan-selective bioconjugation of proteins.2016

    • Author(s)
      Yohei Seki, Takashi Ishiyama, Daisuke Sasaki, Junpei Abe, Youhei Sohma, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Journal of the American Chemical Society

      Volume: 138 Issue: 34 Pages: 10798-10801

    • DOI

      10.1021/jacs.6b06692

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Elementary and systemic views of the generation of toxic substances2016

    • Author(s)
      Takayuki Wakaki,Kounosuke Oisakia and Motomu Kanai*
    • Journal Title

      Green Chemistry

      Volume: 18 Issue: 13 Pages: 3681-3683

    • DOI

      10.1039/c6gc90058e

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Chemo- and Regioselective Oxygenation of C(sp3)-H Bonds in Aliphatic Alcohols Using a Covalently Bound Directing Activator and Atmospheric Oxygen2016

    • Author(s)
      Jun Ozawa, Masayuki Tashiro, Jizhi Ni, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Chemical Science

      Volume: 7 Issue: 3 Pages: 1904-1909

    • DOI

      10.1039/c5sc04476f

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhanced structural variety of nonplanar N-oxyl radical catalysts and their application to the aerobic oxidation of benzylic C-H bonds2016

    • Author(s)
      Yoichi Kadoh, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Chemistry Pharmaceutical Bulletin

      Volume: 未定

    • NAID

      130005160056

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Organocatalytic aerobic oxidation of α-fluoroalkyl alcohols to fluoroalkyl ketones at room temperature2015

    • Author(s)
      Yoichi Kadoh, Masayuki Tashiro, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Advanced Synthesis & Catalysis

      Volume: 357(10) Issue: 10 Pages: 2193-2198

    • DOI

      10.1002/adsc.201500131

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Metal-free C(3)-H arylation of coumarins promoted by catalytic amounts of 5,10,15,20-tetrakis(4-diethylaminophenyl)porphyrin2015

    • Author(s)
      Masahiro Kojima, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Chemical Communications

      Volume: 51 Issue: 47 Pages: 9718-9721

    • DOI

      10.1039/c5cc02349a

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Asparagine-Selective Cleavage of Peptide Bonds through Hypervalent Iodine-Mediated Hofmann Rearrangement in Neutral Aqueous Solution2014

    • Author(s)
      Kana Tanabe, Atsuhiko Taniguchi, Takuya Matsumoto, Kounosuke Oisaki, Youhei Sohma, Motomu Kanai
    • Journal Title

      Chem. Sci.

      Volume: 5 Issue: 7 Pages: 2747-2753

    • DOI

      10.1039/c3sc53037j

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serine-selective aerobic cleavage of peptides and a protein using water-soluble copper-organoradical conjugate2014

    • Author(s)
      Yohei Seki, Kana Tanabe, Daisuke Sasaki, Youhei Sohma, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 53 Issue: 25 Pages: 6501-6505

    • DOI

      10.1002/anie.201402618

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chemoselective aerobic photo-oxidation of 9H-fluorenes for the synthesis of 9-fluorenones2014

    • Author(s)
      Masahiro Kojima, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Tetrahedron Letters

      Volume: 55 Issue: 34 Pages: 4736-4738

    • DOI

      10.1016/j.tetlet.2014.06.038

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] アミンの穏和な酸素酸化反応および環境調和型酸化カップリングを進行させる銅/keto-ABNO触媒系2014

    • Author(s)
      生長幸之助、園部敏亮、金井求
    • Journal Title

      和光純薬時報

      Volume: 82 Pages: 2-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemoselective Aerobic Oxidation Catalyzed by a Metal/Stable Organoradical Redox Conjugate2014

    • Author(s)
      Yohei Seki, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Tetrahedron Letters

      Volume: 55 Issue: 28 Pages: 3738-3746

    • DOI

      10.1016/j.tetlet.2014.05.085

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] How &ldquo;Blog&rdquo; is Changing Researches in Synthetic Chemistry?2014

    • Author(s)
      生長幸之助
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 72 Issue: 1 Pages: 74-78

    • DOI

      10.5059/yukigoseikyokaishi.72.74

    • NAID

      130003395375

    • ISSN
      0037-9980, 1883-6526
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Manganese-Catalyzed Aerobic Dehydrogenative Cyclization toward Ring-Fused Indole Skeletons2013

    • Author(s)
      Oisaki, K.; Abe, J.; Kanai, M.
    • Journal Title

      Org. Biomol. Chem.

      Volume: 11 Issue: 28 Pages: 4569-4572

    • DOI

      10.1039/c3ob40855h

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] From Chiral Base Catalysts to Redox-Active Catalysts: Chasing the Identity of Metal Catalysts in Carbon-Carbon Bond-Forming Reactions2013

    • Author(s)
      金井求、松永茂樹、 生長幸之助 、清水洋平
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 71 Issue: 5 Pages: 433-442

    • DOI

      10.5059/yukigoseikyokaishi.71.433

    • NAID

      10031171534

    • ISSN
      0037-9980, 1883-6526
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 遷移金属フリーなトリプトファン選択的タンパク質共役反応の開発2017

    • Author(s)
      関陽平、石山隆史、佐々木大輔、阿部純平、相馬洋平、生長幸之助、金井求
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター・東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規生体共役反応を用いる均一ADCへのアプローチ2017

    • Author(s)
      石山隆史、関陽平、生長幸之助、金井求
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター・東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規ペプチドチオ酸合成法の開発とペプチドのカップリングへの応用2017

    • Author(s)
      平野遼、松本拓也、生長幸之助、金井求
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター・東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] リガンドフリー銅触媒を用いたベンジル位sp3 C-H酸素酸化反応の開発2017

    • Author(s)
      田中博隆、生長幸之助、金井求
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター・東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] アルコール可逆的分子認識を利用した位置選択的C(sp3)-H酸化反応触媒の開発研究2017

    • Author(s)
      坂井健太郎、田代真之、生長幸之助、金井求
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター・東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 安定な低会合状態を示すアミロイドβ修飾体の創製2017

    • Author(s)
      阿部 純平、佐々木 大輔、関 陽平、相馬 洋平、生長 幸之助、金井 求
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター・東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 低露出度アミノ酸選択的なタンパク質生体共役反応の開発2017

    • Author(s)
      生長幸之助、関陽平、石山隆史、佐々木大輔、阿部純平、相馬洋平、金井求
    • Organizer
      リバネス第6回超異分野学会
    • Place of Presentation
      秋葉原UDX(東京都千代田区)
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Chemoselective Protein Modifications Using Organoradicals2017

    • Author(s)
      生長幸之助
    • Organizer
      第23回ペプチドフォーラム
    • Place of Presentation
      東京大学(東京都文京区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ラジカル共役型レドックス触媒が拓く新規選択的酸化反応2017

    • Author(s)
      生長幸之助
    • Organizer
      2016年度 第2回 有機金属若手研究者の会, 東京理科大学, 東京, 2017年3月15日
    • Place of Presentation
      東京理科大学(東京都新宿区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Transition Metal-Free, Tryptophan-Selective Bioconjugation of Proteins2017

    • Author(s)
      Kounosuke Oisaki, Yohei Seki, Takashi Ishiyama, Daisuke Sasaki, Junpei Abe, Youhei Sohma, Motomu Kanai
    • Organizer
      3rd International Symposium for Medicinal Sciences
    • Place of Presentation
      Sendai International Center (JAPAN)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Amyloid-selective catalytic photooxygenation with long-wavelength light irradiation2016

    • Author(s)
      Atsuhiko Taniguchi, Jizhi Ni, Yusuke Shimizu, Shuta Ozawa, Yukiko Hori, Taisuke Tomita, Kounosuke Oisaki, Yoichiro Kuninobu, Youhei Sohma, Motomu Kanai
    • Organizer
      Amyloid-selective catalytic photooxygenation with long-wavelength light irradiation Peptide and Protein Society in Singapore Symposium
    • Place of Presentation
      Nanyang Technological University (SINGAPORE)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 遷移金属フリーなトリプトファン選択的タンパク質共役反応の開発2016

    • Author(s)
      生長幸之助
    • Organizer
      第9回有機触媒シンポジウム
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アミロイド疾患の治療を指向した選択的光酸素化触媒の開発2016

    • Author(s)
      相馬洋平,谷口敦彦,倪 積智,清水裕介,生長幸之助,小澤柊太、堀由起子、富田 泰輔、金井求
    • Organizer
      第34回メディシナル ケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Chemoselective Protein Modifications Using Organoradicals2016

    • Author(s)
      生長幸之助
    • Organizer
      精密制御反応場 第 1 回国際若手セミナー
    • Place of Presentation
      みのお山荘(大阪府箕面市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 遷移金属フリーなトリプトファン選択的タンパク質共役反応の開発2016

    • Author(s)
      生長幸之助、関陽平、石山隆史、佐々木大輔、阿部純平、相馬洋平、金井求
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      清水文化会館マリナート(静岡県清水市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Transition Metal-Free Tryptophan-Selective Bioconjugation of Proteins2016

    • Author(s)
      Takashi Ishiyama, Yohei Seki, Daisuke Sasaki, Junpei Abe, Youhei Sohma, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      第33回 有機合成化学セミナー
    • Place of Presentation
      ヒルトンニセコビレッジ(北海道ニセコ市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Directing activator-assisted regio- and oxidation state-selective aerobic oxidation of secondary C(sp3)-H bonds in aliphatic alcohols2016

    • Author(s)
      Kounosuke Oisaki, Jizhi Ni, Jun Ozawa, Masayuki Tashiro, Motomu Kanai
    • Organizer
      The 15th Belgian Organic Synthesis Symposium (BOSS XV)
    • Place of Presentation
      University of Antwerp (BELGIUM)
    • Year and Date
      2016-07-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serine-Selective Aerobic Cleavage of Peptides and a Protein Using Water-Soluble Copper-Organoradical Conjugate2016

    • Author(s)
      Yohei Seki, Kana Tanabe, Daisuke Sasaki, Youhei Sohma, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      17th Tetrahedron Symposium
    • Place of Presentation
      Sitge(SPAIN)
    • Year and Date
      2016-06-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo への適用を目指したアミロイドβ選択的光酸素化触媒の開発2016

    • Author(s)
      谷口敦彦、清水裕介、倪積智、生長幸之助、國信洋一郎、相馬洋平、金井求
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規ペプチドチオ酸合成法の開発とペプチドカップリングへの応用2016

    • Author(s)
      平野 遼、松本 拓也、生長 幸之助、金井 求
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 無金属ポルフィリン誘導体を用いたクマリンC(3)-Hアリール化反応の開発2016

    • Author(s)
      小島 正寛、生長 幸之助、金井 求
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] イリジウム-N-ヘテロ環状カルベン(NHC)共役型ラジカル錯体の創製とその触媒応用研究2016

    • Author(s)
      金子 敬一、生長 幸之助、金井 求
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 遷移金属を用いないトリプトファン選択的天然タン パク質生体共役反応の開発2016

    • Author(s)
      石山 隆史, 関 陽平, 佐々木 大輔, 阿部 純平 , 相 馬 洋平, 生長 幸之助 1, 金井 求
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 病原性アミロイドタンパク質に対する生体適応型光酸素化触媒の開発2016

    • Author(s)
      谷口 敦彦、清水 裕介、倪 積智、生長 幸之助、國信 洋一郎、相馬 洋平、金井 求
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of Residue-Selective Bioconjugation Targeting Native Proteins Using Organoradicals2016

    • Author(s)
      Youhei Seki, Takashi Ishiyama, Daisuke Sasaki, Junpei Abe, Youhei Sohma, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学 京田辺キャンパス(京都)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Biocompatible Photooxygenation Catalyst that Targets Amyloid Aggregation2016

    • Author(s)
      Youhei Sohma, Atsuhiko Taniguchi, Yusuke Shimizu, Jizhi Ni, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      第8回武田科学振興財団薬科学シンポジウム
    • Place of Presentation
      武田薬品研修所(大阪)
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規ペプチドチオ酸合成法の開発とペプチドのカップリングへの応用2016

    • Author(s)
      平野遼、松本拓也、生長幸之助、金井求
    • Organizer
      第51回天然物化学談話会
    • Place of Presentation
      湯沢東映ホテル(新潟県南魚沼郡)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 有機ラジカルを用いた化学選択的タンパク質変換法の開発2016

    • Author(s)
      生長幸之助
    • Organizer
      若手研究者のための有機化学札幌セミナー
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 有機ラジカルを用いた化学選択的タンパク質変換法の開発2016

    • Author(s)
      生長幸之助
    • Organizer
      2nd Joint Workshop on Chirality in Chiba University and Soft Molecule Activation
    • Place of Presentation
      千葉大学(千葉県千葉市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Chemo- and Siteselective Aerobic Oxygenation of sp3 C-H Bonds of Alcohols Using N-Oxyl Radical Directing Activator2015

    • Author(s)
      Kounosuke Oisaki, Jun Ozawa, Jizhi Ni, Masayuki Tashiro, Motomu Kanai
    • Organizer
      The International Chemical Congress of Pacific Basin Societies(Pacifichem 2015)
    • Place of Presentation
      Hawaii Convention Center, Honolulu (HI, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Biocompatible Photooxygenation Catalyst that Targets Amyloid Aggregation2015

    • Author(s)
      Youhei Sohma, Atsuhiko Taniguchi, Yusuke Shimizu, Jizhi Ni, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      7th International Peptide Symposium
    • Place of Presentation
      Matrix Biopolis (Singapore)
    • Year and Date
      2015-12-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 配向活性基を用いた分子状酸素による化学・位置選択的炭素-水素結合酸素化反応の開発2015

    • Author(s)
      田代 真之, 小澤 淳, Ni Jizhi, 生長 幸之助, 金井 求
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      早稲田大学 国際会議場(東京)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] DEVELOPMENT OF ON/OFF SWITCHABLE PHOTOOXYGENATION CATALYST SENSING PATHOGENIC AMYLOID STRUCTURE2015

    • Author(s)
      Atsuhiko Taniguchi, Yusuke Shimizu, Jizhi Ni, Kounosuke Oisaki, Yoichiro Kuninobu, Youhei Sohma, Motomu Kanai
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚中央公民館(神奈川)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Metal-free C(3)-H arylation of coumarins promoted by catalytic amounts of 5,10,15,20-tetrakis(4-diethylaminophenyl)porphyrin2015

    • Author(s)
      Masahiro Kojima, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      The 3rd International Symposium on Process Chemistry (ISPC2015)
    • Place of Presentation
      京都国際会議センター(京都)
    • Year and Date
      2015-07-13
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of protecting group- and coupling reagent-minimized peptide bond-forming reaction2015

    • Author(s)
      松本拓也、生長幸之助、金井求
    • Organizer
      2015 年度GPLLI 全体会議
    • Place of Presentation
      東京大学安田講堂(東京)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
  • [Presentation] アミロイドタンパク質の高次構造を認識する on / off スイッチ可能な光酸素化触媒2015

    • Author(s)
      谷口 敦彦,清水 裕介,倪 積智、生長 幸之助、國信 洋一郎,相馬 洋平,金井 求
    • Organizer
      日本ケミカルバイオロジー学会 第10回年会
    • Place of Presentation
      東北大学川内キャンパス萩ホール(宮城)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 有機ラジカルを用いる残基選択的タンパク質生体共役反応の開発2015

    • Author(s)
      生長幸之助、関陽平、阿部純平、佐々木大輔、相馬洋平、金井求
    • Organizer
      日本ケミカルバイオロジー学会 第10回年会
    • Place of Presentation
      東北大学川内キャンパス萩ホール(宮城)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 無金属ポルフィリン誘導体を用いたクマリンC(3)-Hアリール化反応の開発2015

    • Author(s)
      小島正寛、生長幸之助、金井求
    • Organizer
      第69回有機合成化学協会関東支部シンポジウム
    • Place of Presentation
      横浜国立大学(神奈川)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Research-status Report
  • [Presentation] ホウ素-トリフルオロメチル結合を持つジピリン-ホウ素錯体の合成2015

    • Author(s)
      清水裕介, 谷口敦彦, 生長幸之助, 國信洋一郎, 相馬洋平, 金井求
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学船橋キャンパス(千葉)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of Residue-Selective Bioconjugation Targeting Native Proteins Using Organoradicals2015

    • Author(s)
      関陽平、阿部純平、豊田洋介、相馬洋平、生長幸之助、金井求
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学船橋キャンパス(千葉)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 基質認識部位を持つ触媒によるC(sp3)-H結合酸化反応の開発研究2015

    • Author(s)
      田代真之、生長幸之助、金井求
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学船橋キャンパス(千葉)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 保護基と縮合剤の使用を最小限に抑えたクリーンな触媒的ペプチド合成法の開発2015

    • Author(s)
      松本拓也、生長幸之助、相馬洋平、金井求
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] インドキサマイシン類の合成研究2015

    • Author(s)
      橋詰祥伍、生長幸之助、金井求
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] アルツハイマー病の化学基盤解明を指向した化学修飾型アミロイドβ合成法の開発2015

    • Author(s)
      阿部純平、関陽平、相馬洋平、生長幸之助、金井求
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 基質認識部位を持つN-オキシルラジカル触媒による位置選択的sp3C-H 結合酸化反応の開発研究2015

    • Author(s)
      生長幸之助、田代真之、金井求
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Serine-Selective Aerobic Cleavage of Peptides and a Protein Using Water-Soluble Copper-Organoradical Conjugate2014

    • Author(s)
      Kounosuke Oisaki, Yohei Seki, Kana Tanabe, Daisuke Sasaki, Youhei Sohma, Motomu Kanai
    • Organizer
      The 9th International Conference on Cutting-Edge Organic Chemistry in Asia / The 5th New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-9/ NICCEOCA-5)
    • Place of Presentation
      Eastin Hotel Petaling Jaya (Selangor, MALAYSIA)
    • Year and Date
      2014-12-01 – 2014-12-04
    • Related Report
      2014 Research-status Report
  • [Presentation] アミロイド病治療を指向したアミロイド高選択的光酸素化触媒の開発2014

    • Author(s)
      谷口敦彦,清水裕介,生長幸之助,相馬洋平,金井 求
    • Organizer
      第32回メディシナルケミストリーシンポジウム
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2014-11-26 – 2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of amyloid β-selective photooxygenation catalyst toward treatment of Alzheimer diseas2014

    • Author(s)
      Yusuke Shimizu, Atsuhiko Taniguchi, Kounosuke Oisaki, Youhei Sohma, Motomu Kanai
    • Organizer
      2nd International Conference & 7th Symposium on Organocatalysis
    • Place of Presentation
      The University of Tokyo (東京)
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Regioselective Aerobic Oxygenation of sp3 C-H Bonds of Alcohols Using N-Oxyl Radical Directing Activator2014

    • Author(s)
      Masayuki Tashiro, Jun Ozawa, Jizhi Ni, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      2nd International Conference & 7th Symposium on Organocatalysis
    • Place of Presentation
      The University of Tokyo (東京)
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] アミロイド高選択的な酸素化触媒の開発2014

    • Author(s)
      相馬洋平、谷口敦彦、清水裕介、生長幸之助、富田泰輔、金井求
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      東北大学 川内萩ホール(宮城)
    • Year and Date
      2014-11-10 – 2014-11-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 配向活性化基を用いたC(sp3)-H酸素化反応の開発2014

    • Author(s)
      小澤淳、倪積智、田代真之、生長幸之助、金井求
    • Organizer
      第106回有機合成シンポジウム2014年【秋】
    • Place of Presentation
      早稲田大学18号館 国際会議場(東京)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Amyloid-Selective Photooxygenation by On/Off Switchable Catalyst2014

    • Author(s)
      Atsuhiko Taniguchi, Yusuke Shimizu, Kounosuke Oisaki, Youhei Sohma, Motomu Kanai
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島大 大塚講堂(徳島)
    • Year and Date
      2014-10-22 – 2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Selective Aerobic Oxygenation of sp3 C-H Bonds of Alcohols Using N-Oxyl Radical Activator2014

    • Author(s)
      Masayuki Tashiro, Jun Ozawa, Jizhi Ni, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      有機合成化学セミナー
    • Place of Presentation
      志賀島(福岡)
    • Year and Date
      2014-07-17 – 2014-07-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Synthesis of 9-fluorenones via selective photo-oxidation of 9H-fluorenes2014

    • Author(s)
      Masahiro Kojima, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      XXVI International Conference on Organometallic Chemistry (ICOMC2014)
    • Place of Presentation
      Royton Sapporo Hotel (北海道)
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Serine-Selective Aerobic Cleavage of Peptides and a Protein Using Water-Soluble Copper-Organoradical Conjugate2014

    • Author(s)
      Kounosuke Oisaki, Yohei Seki, Kana Tanabe, Daisuke Sasaki, Youhei Sohma, Motomu Kanai
    • Organizer
      19th International Symposium on Homogeneous Catalysis (ISHC-IXX)
    • Place of Presentation
      Ottawa Convention Centre (Ottawa, CANADA)
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] O2/NOx-Promoted Site- and Oxidation State-Selective C(sp3)-H Oxidation2014

    • Author(s)
      Jizhi Ni, Jun Ozawa, Masayuki Tashiro, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      The International Conference on Hydrogen Atom Transfer (iCHAT 2014)
    • Place of Presentation
      Villa Mondragone (Monteporzio Catone, ITALY)
    • Year and Date
      2014-06-22 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 超原子価ヨウ素を用いたアスパラギン選択的ペプチド結合切断法2014

    • Author(s)
      田辺佳奈、谷口敦彦、松本拓也、生長幸之助、相馬洋平、金井求
    • Organizer
      日本ケミカルバイオロジー学会 第9回年会
    • Place of Presentation
      大阪大学会館(大阪)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] セリン選択的酸化的ペプチド鎖切断法2014

    • Author(s)
      関陽平、田辺佳奈、佐々木大輔、相馬洋平、生長幸之助、金井求
    • Organizer
      日本ケミカルバイオロジー学会 第9回年会
    • Place of Presentation
      大阪大学会館(大阪)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] A Catalytic Oxidation of Benzylic C(sp3)-H Bonds Utilizing Molecular Oxygen2014

    • Author(s)
      Shogo Hashizume, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      The French-American Chemical Society 15th Meeting (FACS XV)
    • Place of Presentation
      Avignon Grand Hotel (Avignon, FRANCE)
    • Year and Date
      2014-06-01 – 2014-06-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Room Temperature-Catalytic β-C-H Functionalization of Amines2014

    • Author(s)
      Toshiaki Sonobe, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      The French-American Chemical Society 15th Meeting (FACS XV)
    • Place of Presentation
      Avignon Grand Hotel (Avignon, FRANCE)
    • Year and Date
      2014-06-01 – 2014-06-05
    • Related Report
      2014 Research-status Report
  • [Presentation] セリン選択的酸化的ペプチド鎖切断法2014

    • Author(s)
      関陽平、田辺佳奈、相馬洋平、生長幸之助、金井求
    • Organizer
      第12回次世代を担う有機化学シンポジウム
    • Place of Presentation
      長井記念ホール(東京)
    • Year and Date
      2014-05-23 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Asparagine-Selective Cleavage of Peptide Bonds in Neutral Aqueous Solutions2014

    • Author(s)
      Kana Tanabe, Atsuhiko Taniguchi, Takuya Matsumoto, Kounosuke Oisaki, Youhei Sohma, Motomu Kanai
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学(愛知)
    • Related Report
      2013 Research-status Report
  • [Presentation] セリン選択的酸化的ペプチド鎖切断法2014

    • Author(s)
      関陽平、田辺佳奈、佐々木大輔、相馬洋平、生長幸之助、金井求
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学(愛知)
    • Related Report
      2013 Research-status Report
  • [Presentation] Site-Selective Aerobic Oxygenation of sp3 C-H Bonds of Alcohols Covalently Bound to N-Oxyl Radical Activator2014

    • Author(s)
      Kounosuke Oisaki, Jun Ozawa, Jizhi Ni, Masayuki Tashiro, Motomu Kanai
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学(愛知)
    • Related Report
      2013 Research-status Report
  • [Presentation] 中性水溶液中におけるアスパラギン選択的なペプチド結合切断法2014

    • Author(s)
      田辺佳奈、谷口敦彦、松本拓也、生長幸之助、相馬洋平、金井求
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本)
    • Related Report
      2013 Research-status Report
  • [Presentation] セリン選択的酸化的ペプチド鎖切断法2014

    • Author(s)
      関陽平、田辺佳奈、佐々木大輔、相馬洋平、生長幸之助、金井求
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本)
    • Related Report
      2013 Research-status Report
  • [Presentation] Ru(bpy)32+-Cu(I)光レドックスリレー触媒によるsp3 C-H結合光酸素酸化反応の開発2014

    • Author(s)
      小島正寛、生長幸之助、金井求
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本)
    • Related Report
      2013 Research-status Report
  • [Presentation] NOx-Promoted Site- and Oxidation State- Selective C(sp3)-H Oxidation2014

    • Author(s)
      Jizhi Ni, Jun Ozawa, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本)
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of Catalytic Dehydrogenative Cyclization Reaction toward Rapid Construction of Ring-Fused Indole Skeleton2013

    • Author(s)
      Junpei Abe, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      The 23rd French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Crown Plaza ANA Nagasaki Gloverhill (Nagasaki)
    • Related Report
      2013 Research-status Report
  • [Presentation] 触媒的酸素活性化を指向したsp3 C-H光酸化反応の開発2013

    • Author(s)
      小島正寛、生長幸之助、金井求
    • Organizer
      第48回天然物化学談話会
    • Place of Presentation
      アヤハレークサイドホテル(滋賀)
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規触媒的酸素酸化反応を用いたセリン選択的人工ペプチダーゼの開発2013

    • Author(s)
      関陽平、園部敏亮、生長幸之助、金井求
    • Organizer
      第48回天然物化学談話会
    • Place of Presentation
      アヤハレークサイドホテル(滋賀)
    • Related Report
      2013 Research-status Report
  • [Presentation] 分子酸素を用いた単純アルコールの位置選択的C-H酸素化反応の開発2013

    • Author(s)
      小澤淳、倪積智、生長幸之助、金井求
    • Organizer
      第48回天然物化学談話会
    • Place of Presentation
      アヤハレークサイドホテル(滋賀)
    • Related Report
      2013 Research-status Report
  • [Presentation] Fe-Catalyzed Oxidative C(3)-Functionalization of Amines2013

    • Author(s)
      Kounosuke Oisaki, Noriaki Takasu, Motomu Kanai
    • Organizer
      Frontiers in Chemistry Armenia (ArmChemFront2013)
    • Place of Presentation
      Ani Plaza Hotel (Yerevan, Armenia)
    • Related Report
      2013 Research-status Report
  • [Presentation] 鉄触媒を用いたアミン類の酸化的3位官能基化反応2013

    • Author(s)
      高須典明、生長幸之助、金井求
    • Organizer
      第43回複素環化学討論会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Related Report
      2013 Research-status Report
  • [Presentation] Asparagine-Selective Cleavage of Peptide Bonds by Hypervalent Iodine2013

    • Author(s)
      Kana Tanabe, Atsuhiko Taniguchi, Takuya Matsumoto, Kounosuke Oisaki, Youhei Sohma, Motomu Kanai
    • Organizer
      4th Asia-Pacific International Peptide Symposium (in conjunction with the 50th Japanese Peptide Symposium)
    • Place of Presentation
      Hotel Hankyu Expo Park (大阪)
    • Related Report
      2013 Research-status Report
  • [Presentation] Aerobic photooxidation of benzylic sp3 C-H bonds by Ru(bpy)32+-Cu(I) cooperative catalysis2013

    • Author(s)
      小島正寛、生長幸之助、金井求
    • Organizer
      GPLLI 1st Colloquium
    • Place of Presentation
      東京大学武田ホール(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of protecting group- and coupling reagent-minimized peptide bond-forming reaction2013

    • Author(s)
      松本拓也、生長幸之助、金井求
    • Organizer
      GPLLI 1st Colloquium
    • Place of Presentation
      東京大学武田ホール(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of novel methodology for complex molecule synthesis and its application to synthesis of bioactive molecules2013

    • Author(s)
      橋詰祥伍、生長幸之助、金井求
    • Organizer
      GPLLI 1st Colloquium
    • Place of Presentation
      東京大学武田ホール(東京)
    • Related Report
      2013 Research-status Report
  • [Remarks] 金井研究室論文リスト2016

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/publication/2016.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 金井研究室論文リスト2017

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/publication/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 金井研究室論文リスト2015

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/publication/2015.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 金井研究室論文リスト2015

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/publication/index.html

    • Related Report
      2015 Research-status Report 2014 Research-status Report
  • [Remarks] 金井研究室論文リスト2014

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/publication/2014.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 金井研究室 論文リスト2014

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/publication/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 金井研究室 論文リスト2013

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/publication/2013.html

    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] インドール構造選択的架橋剤およびそれを用いた複合体2017

    • Inventor(s)
      金井求、生長幸之助、関陽平、佐々木大輔、石山隆史
    • Industrial Property Rights Holder
      株式会社東京大学TLO
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ABNO誘導体により架橋されている複合体およびその製造方法2016

    • Inventor(s)
      金井求、生長幸之助、関陽平、佐々木大輔、石山隆史
    • Industrial Property Rights Holder
      金井求、生長幸之助、関陽平、佐々木大輔、石山隆史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-03-09
    • Related Report
      2015 Research-status Report
    • Overseas

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Published: 2014-07-25   Modified: 2019-07-29  

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