| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
There were only a few examples of kinetic resolution of racemic amines by chiral catalysts when optically active amides are prepared from carboxylic acids and amines. In contrast, a chiral catalyst developed in this study recognized stereogenic centers of carboxylic acids in a triazine-based dehydrocondensing reaction. It was elucidated that structures of chiral tertiary amines and chlorotriazines affected enantio-selectivity of the products. This is a first catalytic reaction system that would afford chiral amides from racemic carboxylic acids, and therefore, it would be useful for development of pharmaceutical drugs. In addition, by using knowledge obtained in this study, novel triazine-based benzylating reagents and effective elimination reactions of triazinylammonium salts were developed.
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