Novel synthesis of nitrogen containing heterocycles using rearrangement reactions of haloamines
Project/Area Number |
25460014
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Osaka University |
Principal Investigator |
Murai Kenichi 大阪大学, 薬学研究科, 助教 (70532068)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 複素環化学 / 転位反応 / 酸化反応 / ハロアミン / インドール / アミナール / ワンポット反応 / 有機化学 |
Outline of Final Research Achievements |
The development of an efficient synthetic method for nitrogen-containing heterocyclic compounds is highly important, because they are contained in a large number of biologically active compounds. In this research, we conducted the study on the rearrangement reaction of haloamines (nitrogen-halogen compounds), an electrophilic nitrogen source, to develop a new synthesis method for nitrogen-containing compounds. As a results, we have found that the rearrangement reactions of haloamines having electron-donating groups such as a nitrogen atom, an oxygen atom, and aromatic substituents occur efficiently and shown their usefulness for the heterocyclic synthesis.
|
Report
(5 results)
Research Products
(32 results)