Development of insulin-release nanocapsules based on novel response mechanism
| Project/Area Number |
25460031
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
Sato Katsuhiko 東北大学, 薬学研究科(研究院), 助教 (80400266)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 機能性薄膜 / ドラックデリバリーシステム / カプセル / インスリン / フェニルボロン酸 / 過酸化水素 / マクロカプセル / インスリンＤＤＳ / ナノカプセル / 交互累積膜 / マイクロカプセル / グルコース |
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| Outline of Final Research Achievements |
Glucose-sensitive multilayer thin films were prepared by a layer-by-layer (LbL) deposition of phenylboronic acid (PBA)-bearing polyelectrolytes and poly(vinyl alcohol) (PVA) on the surface of glucose oxidase (GOx)-modified quartz slide. PBA and PVA layers were connected with each other through boronate ester bonds while GOx was immobilized electrostatically interactions. The films were stable in wide pH range from 3.0 to 9.0 in the absence of glucose. In contrast, the films decomposed in the presence of glucose. The glucose-induced decomposition of the film can be rationalized based on the scission of the carbon―boron bond of PBA residues in PBA-polymer chains by hydrogen peroxide (H2O2) produced through the GOx-catalyzed oxidation reaction of glucose. The glucose-sensitive multilayer film may be useful for constructing insulin delivery systems.
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Report
(4 results)
Research Products
(11 results)
