Design of supramolecular complexes to form asymmetry nanotube structure and the application for controlled release carrier
| Project/Area Number |
25460032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
Yamamoto Keiji 千葉大学, 薬学研究科(研究院), 名誉教授 (50110341)
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| Co-Investigator(Kenkyū-buntansha) |
MORIBE Kunikazu 千葉大学, 大学院薬学研究院, 教授 (50266350)
HIGASHI Kenjirou 千葉大学, 大学院薬学研究院, 講師 (40451760)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 分子製剤学 / 有機ナノチューブ / シクロデキストリン / 分子状態 / 薬物溶解性 / 放出制御 / 固体NMR / 難水溶性薬物 / 超分子複合体 / 溶出速度 / 分子間相互作用 / 非晶質 / ナノチューブ / ポリシュードロタキサン / 薬物封入 / 溶解性改善 / 結晶多形 |
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| Outline of Final Research Achievements |
In this study, the relationships between molecular state and dissolution character of guest drug in host materials (organic nanotube and cyclodextrin-polypseudorotaxane) were clarified. The encapsulation ratio and dissolution of guest drug can be controlled by changing the character of host materials. The knowledge obtained in this study will be a help on promoting the application of host materials in pharmaceutical sciences. In the future, new controlled release carriers tailored to therapeutic drug and therapeutic purpose are expected to be developed.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Application of intermolecular spaces between polyethylene glycol/γ-cyclodextrin-polypseudorotaxanes as a host for various guest drugs2014
Author(s)
Higashi, K., Waraya, H., Lin, L. K., Namiki, S., Ogawa, M., Limwikrant, W., Yamamoto, K., Moribe, K.
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Journal Title
Cryst. Growth Des.
Volume: 14 (6)
Issue: 6
Pages: 2773-2781
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Encapsulation of poorly water-soluble drugs into organic nanotubes for improving drug dissolution2014
Author(s)
Moribe, K., Makishima, T., Higashi, K, Liu, N., Limwikrant, W., Ding, W., Masuda, M., Shimizu, T., Yamamoto, K.
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Journal Title
Int. J. Pharm.
Volume: 469 (1)
Issue: 1
Pages: 190-196
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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