Elucidation of mechanism that nitric oxide positively regulate pathology of ulcerative colitis using magnetic resonance technique
| Project/Area Number |
25460037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Daiichi University, College of Pharmaceutical Sciences (2015)
Kyushu University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 一酸化窒素 / 潰瘍性大腸炎 / 大腸炎 |
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| Outline of Final Research Achievements |
In this study, mechanism that excess amount of nitric oxide (NO) produced in ulcerative colitis is involved in the inflammation of colonic mucosa was investigated using the magnetic resonance technique. The scheme was proposed as follows; 1) NO produced from activated macrophages infiltrating into the colonic tissue would trigger the activation of TLR4-NF-kB pathway, which was brought by the CD14 expression enhanced by STAT3 activation. 2) The increase of IL-6 level induced by the activated NF-kB would lead to the further activation of STAT3. 3) The increase of expression of adhesion molecules induced by the activated NF-kB would cause the infiltration of neutrophils producing reactive oxygen species leading to the mucosal injury.
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Report
(4 results)
Research Products
(8 results)
