Physicochemical study on molecular design of a fluorescent probe responding to internal potentials
| Project/Area Number |
25460039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
Uno Bunji 岐阜薬科大学, 薬学部, 教授 (80160307)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 蛍光プローブ / 電位応答 / 光誘起電子移動 / 分子内電子移動 / フェロセン / ダンシル基 / プロトン移動共役電子移動 / オルトカルボラン / カルボラン / クマリン |
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| Outline of Final Research Achievements |
Molecular design of a fluorescent probe responding to internal potentials, useful for innovative drug development against cancer, is discussed from the point of view of function of the crosslinked structure between fluorescent and response groups in the probe. It has been found that efficient photo-induced electron transfer occurs in the crosslinking of a short methylene chain and is inhibited by intermolecular electron transfer in the conjugated crosslinking. In addition, hydroquinone and catechol as well as ferrocene were found to be the good candidates for response groups to internal potential. On the other hand, o-carborane is likely to be the new fluorescent groups in the probes.
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Report
(4 results)
Research Products
(11 results)
