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Possibility of the glycyrrhizic acid as emulsifier for drug and the application to absorption inhibitor of cholesterol

Research Project

Project/Area Number 25460043
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical pharmacy
Research InstitutionSaitama University

Principal Investigator

MATSUOKA Keisuke  埼玉大学, 教育学部, 准教授 (90384635)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsグリチルリチン酸 / ミセル / 会合体 / 臨界ミセル濃度 / 両親媒性分子 / 表面張力
Outline of Final Research Achievements

The glycyrrhizin acid has two carboxylic groups at double glucuronic acids and one carboxylic group on the top of molecule as the hydrophilic part. Therefore, the polyvalent weak acid had a great influence on the surface and aggregate properties depending on the pH of the buffer solutions. The aqueous solubility of glycyrrhizin acid was quite low in the lower pH range. The pH range for micelle formation was quite narrow, from pH 5 to 6. Glycyrrhizic acid forms rod-like micelles.The existence of this aggregate highlights the potential applications of glycyrrhizic acid as an emulsifier and solubilization agent. Glycyrrhizin acid exists as monomer state at pH > 7. Therefore, it is necessary to pay attention to the pH of the solution when this biosurfactant is used as an emulsifier or solubilizer in the practical fields. In future, the aggregation structure based on the specific molecular structure will be examined using similar compounds, glycyrrhetic acid, 3-O-glucuronide.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Aggregate formation of glycyrrhizic acid2016

    • Author(s)
      Keisuke Matsuoka, Ryusuke Miyajima, Yudai Ishida, Seigo Karasawa, Tomokazu Yoshimura
    • Journal Title

      Colloids and Surfaces A: Physicochemical and Engineering Aspects

      Volume: 500 Pages: 112-117

    • DOI

      10.1016/j.colsurfa.2016.04.032

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Aggregation formation of Glycyrrhizic acids2015

    • Author(s)
      Keisuke Matsuoka, Ryusuke Miyajima, Tomokazu Yoshimura
    • Organizer
      6th Asian Conference on Colloid and Interface Science,ACCIS
    • Place of Presentation
      アルカス佐世保 (長崎県・佐世保市)
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グリチルリチン酸類水溶液の表面物性と会合体形成2015

    • Author(s)
      松岡圭介, 宮嶋 龍介
    • Organizer
      第54会日本油化学会年会
    • Place of Presentation
      名城大学 (愛知県・名古屋市)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] グリチルレチン酸3‐O‐グルクロニドの会合体形成2014

    • Author(s)
      岡圭介、唐澤正悟
    • Organizer
      日本油化学会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] グリチルリチン酸の会合体形成2013

    • Author(s)
      松岡圭介、寺澤 翔里、唐澤 正悟、小池 信吾
    • Organizer
      第64回コロイドおよび界面化学討論会
    • Place of Presentation
      名古屋工業大学 (愛知県)
    • Related Report
      2013 Research-status Report
  • [Remarks] 研究概要、研究論文リンク先

    • URL

      http://park.saitama-u.ac.jp/~matsuokakei/index.html

    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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