| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The glycyrrhizin acid has two carboxylic groups at double glucuronic acids and one carboxylic group on the top of molecule as the hydrophilic part. Therefore, the polyvalent weak acid had a great influence on the surface and aggregate properties depending on the pH of the buffer solutions. The aqueous solubility of glycyrrhizin acid was quite low in the lower pH range. The pH range for micelle formation was quite narrow, from pH 5 to 6. Glycyrrhizic acid forms rod-like micelles.The existence of this aggregate highlights the potential applications of glycyrrhizic acid as an emulsifier and solubilization agent. Glycyrrhizin acid exists as monomer state at pH > 7. Therefore, it is necessary to pay attention to the pH of the solution when this biosurfactant is used as an emulsifier or solubilizer in the practical fields. In future, the aggregation structure based on the specific molecular structure will be examined using similar compounds, glycyrrhetic acid, 3-O-glucuronide.
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