| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Polymeric nanoparticle and polymeric micelles were designed as drug carrier for treatment of periodontal disease. In this study, we established evaluation method of in vitro anti-inflammatory effect with macrophage cell under cocultivation with P. gingivalis. Nanocarriers shows strongly suppression of cytokine production compared with drug solution. Furthermore, deeply penetration of nanocarriers into the periodontal tissue were observed with the confocal laser scanning microscopy. Nanocarrier indicated the strongly anti-bacterial effect by biofilm retraction effect. We could successfully prepare the nano drug carrier for treatment of periodontal disease.
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