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Design of polymeric nanoparticle for treatment of periodontal disease

Research Project

Project/Area Number 25460046
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical pharmacy
Research InstitutionAichi Gakuin University

Principal Investigator

Yamamoto Hiromitsu  愛知学院大学, 薬学部, 教授 (30275094)

Co-Investigator(Kenkyū-buntansha) MITSUO FUKUDA  愛知学院大学, 歯学部, 教授 (40156790)
TADAHIDE FURUNO  愛知学院大学, 薬学部, 教授 (80254308)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords高分子ナノ粒子 / 歯周病 / 歯周組織浸透性 / バイオフィルム感染症 / ドラッグデリバリーシステム / 高分子ミセル / バイオフィルム / 嫌気性菌 / ナノ粒子
Outline of Final Research Achievements

Polymeric nanoparticle and polymeric micelles were designed as drug carrier for treatment of periodontal disease. In this study, we established evaluation method of in vitro anti-inflammatory effect with macrophage cell under cocultivation with P. gingivalis. Nanocarriers shows strongly suppression of cytokine production compared with drug solution. Furthermore, deeply penetration of nanocarriers into the periodontal tissue were observed with the confocal laser scanning microscopy. Nanocarrier indicated the strongly anti-bacterial effect by biofilm retraction effect. We could successfully prepare the nano drug carrier for treatment of periodontal disease.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2013

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] Observation of antibacterial effect of biodegradable polymeric nanoparticles on Staphylococcus epidermidis biofilm using FE-SEM with an ionic liquid.2015

    • Author(s)
      Takahashi, C., Ogawa, N., Kawashima, Y., Yamamoto, H.
    • Journal Title

      Microscopy

      Volume: 64 Issue: 3 Pages: 169-180

    • DOI

      10.1093/jmicro/dfv010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Electron microscopy of Staphylococcus epidermidis fibril and biofilm formation using image-enhancing ionic liquid.2015

    • Author(s)
      Takahashi C, Kalita G, Ogawa N, Moriguchi K, Tanemura M, Kawashima Y, Yamamoto H
    • Journal Title

      Anal Bioanal Chem.

      Volume: 407 Issue: 6 Pages: 1607-1613

    • DOI

      10.1007/s00216-014-8391-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 球形晶析技術を応用したバイオフィルム感染症治療を目的としたナノ粒子製剤の開発2015

    • Author(s)
      山本浩充・小川法子・高橋知里
    • Journal Title

      Drug Delivery System

      Volume: 30 Pages: 129-136

    • NAID

      130005083739

    • Related Report
      2014 Research-status Report
  • [Presentation] 添加剤粒子の設計から構築する製剤機能2016

    • Author(s)
      山本浩充
    • Organizer
      第15回医薬品添加剤セミナー
    • Place of Presentation
      連合会館(東京都)
    • Year and Date
      2016-02-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 添加剤粒子の設計から構築する製剤機能2016

    • Author(s)
      山本浩充
    • Organizer
      第15回医薬品添加剤セミナー
    • Place of Presentation
      薬業年金会館(大阪府)
    • Year and Date
      2016-02-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 難治性疾患治療用高分子ナノ粒子DDSの設計2015

    • Author(s)
      山本浩充
    • Organizer
      「ライフサイエンスネットワーク形成事業」(医薬品分野)
    • Place of Presentation
      パシフィックホテル沖縄(沖縄県)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Development of Polymeric nanoparticle Carrier for Drug Delivery System and Design as Solid Dosage forms2015

    • Author(s)
      H. Yamamoto
    • Organizer
      ACHEMA2015
    • Place of Presentation
      Messe (Frankfurt am Main, Germany)
    • Year and Date
      2015-06-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Antibacterial Drug Delivery with Nano‐Drug Carrier against Biofilm Infection Disease2013

    • Author(s)
      Hiromitsu Yamamoto, Asami Suda, Akihiro Hoshikawa, Chisato Takahashi, Noriko Ogawa, Yoshiaki Kawashima
    • Organizer
      19th International Symposium on Microencapsulation
    • Place of Presentation
      Pamplona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Design of polymeric micelle to treat for biofilm infection disease2013

    • Author(s)
      Asami Suda, Akihiro Hoshikawa, Noriko Ogawa, Chisato Takahashi, Yoshiaki Kawashima, Hiromitsu Yamamoto
    • Organizer
      5th Asian Arden Conference
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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