Design of polymeric nanoparticle for treatment of periodontal disease
| Project/Area Number |
25460046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MITSUO FUKUDA 愛知学院大学, 歯学部, 教授 (40156790)
TADAHIDE FURUNO 愛知学院大学, 薬学部, 教授 (80254308)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 高分子ナノ粒子 / 歯周病 / 歯周組織浸透性 / バイオフィルム感染症 / ドラッグデリバリーシステム / 高分子ミセル / バイオフィルム / 嫌気性菌 / ナノ粒子 |
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| Outline of Final Research Achievements |
Polymeric nanoparticle and polymeric micelles were designed as drug carrier for treatment of periodontal disease. In this study, we established evaluation method of in vitro anti-inflammatory effect with macrophage cell under cocultivation with P. gingivalis. Nanocarriers shows strongly suppression of cytokine production compared with drug solution. Furthermore, deeply penetration of nanocarriers into the periodontal tissue were observed with the confocal laser scanning microscopy. Nanocarrier indicated the strongly anti-bacterial effect by biofilm retraction effect. We could successfully prepare the nano drug carrier for treatment of periodontal disease.
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Report
(4 results)
Research Products
(9 results)
