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Determination of intra-cellular dynamics of platinum(IV) complexes using imaging technique

Research Project

Project/Area Number 25460047
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical pharmacy
Research InstitutionSuzuka University of Medical Science (2015)
Meijo University (2013-2014)

Principal Investigator

Kojima Nakao  鈴鹿医療科学大学, 医用工学部, その他 (80333178)

Co-Investigator(Kenkyū-buntansha) UEDA Koji  名城大学, 薬学部, 助教 (30351092)
OKAMOTO Yoshinori  名城大学, 薬学部, 助教 (50512323)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords白金4価錯体 / 活性酸素種 / 酸化ストレス / グルタチオン / 薬物耐性 / タイムラプス解析 / ヒト卵巣がん / シスプラチン耐性 / 細胞障害 / 細胞内還元 / 抗がん作用 / 細胞内分布
Outline of Final Research Achievements

Platinum(IV) [Pt(IV)] complexes are one of the attractive next-generation anticancer drugs. Beside Pt(II)-based drugs such as cisplatin, carboplatin, and oxaliplatin, Pt(IV) complexes show less adverse effects and can be administrated orally. In addition, because Pt(IV) complexes adopt octahedral coordination geometry, it also have an advantage that can be coordinated with more functional ligands than Pt(II) complexes. These different features prompted us to investigate the effectiveness of Pt(IV) complexes on cisplatin-resistant cancer cells with its mechanisms. This study aims to elucidate the anti-cancer effects of Pt(IV) complexes.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (11 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats.2015

    • Author(s)
      Okamoto Y., Tobe T., Ueda K., Takada T., Kojima N.
    • Journal Title

      J. Toxicol. Sci.

      Volume: NA

    • NAID

      130004904040

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thiol-mediated multiple mechanisms centered on selenodiglutathione determine selenium cytotoxicity against MCF-7 cancer cells.2015

    • Author(s)
      Tobe T., Ueda K., Ando M., Okamoto Y., Kojima N.
    • Journal Title

      J. Biol. Inorg. Chem.

      Volume: NA

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural Differentiation of Pluripotent Stem Cells and Application for Metal-induced Neural Toxicity Study2014

    • Author(s)
      Taniguchi Y., Tobe T., Hayami H., Okamoto Y., Ueda K., Takada T., Kojima N.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 134 Issue: 7 Pages: 793-795

    • DOI

      10.1248/yakushi.14-00017-3

    • NAID

      130004756445

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2014-07-01
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of organic and inorganic mercury(II) on gene expression via DNA conformational changes.2014

    • Author(s)
      Ueda K., Makino R., Tobe T., Okamoto Y., Kojima N.
    • Journal Title

      Fund. Toxicol. Sci.

      Volume: 1 Pages: 269-280

    • NAID

      130005083332

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of the anticancer effects of cisplatin platinum(IV) derivatives against cisplatin-resistant human ovarian cancer cells.2013

    • Author(s)
      Yoshinori Okamoto, Tsuyoshi Nakai, Motozumi Ando, Nakao Kojima
    • Journal Title

      J. Res. Inst. Meijo Univ.

      Volume: 12 Pages: 35-41

    • Related Report
      2013 Research-status Report
  • [Presentation] 白金4価錯体によるシスプラチン耐性ヒト卵巣がん細胞障害作用への活性酸素種生成の寄与2016

    • Author(s)
      岡本誉士典、植田康次、小嶋仲夫、神野透人
    • Organizer
      日本酸化ストレス学会東海支部 第4回学術集会
    • Place of Presentation
      鈴鹿
    • Year and Date
      2016-02-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cisplatin耐性がん細胞に対するcis-Pt(IV)の細胞障害性と活性酸素種生成2015

    • Author(s)
      戸邊隆夫、清水崇光、棚橋侑也、野中志保、岡本誉士典、植田康次、神野透人
    • Organizer
      メタルバイオサイエンス研究会2015
    • Place of Presentation
      名古屋
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] cis-Diammine-tetrachloro-platinum(IV) は活性酸素種生成を介してシスプラチン耐性ヒト卵巣がん細胞に障害作用を引き起こす2015

    • Author(s)
      戸邊隆夫、清水崇光、野中志保、植田康次、岡本誉士典、小嶋仲夫、神野透人
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Anti-cancer effect of platinum(IV) complex against cisplatin-resistant human ovarian cancer2015

    • Author(s)
      Yoshinori Okamoto, Takao Tobe, Koji Ueda, Nakao Kojima
    • Organizer
      AACR Annual Meeting 2015
    • Place of Presentation
      フィラデルフィア、アメリカ
    • Year and Date
      2015-04-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Anti-cancer effect of platinum(IV) complex against cisplatin-resistant human ovarian cancer2015

    • Author(s)
      Yoshinori Okamoto, Takao Tobe, Koji Ueda, Nakao Kojima
    • Organizer
      American Association for Cancer Research Annual Meeting 2015
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-cancer effects of Pt(IV) complex in cisplatin-resistant ovarian cancer cells2014

    • Author(s)
      Takao Tobe, Karin Shimizu, Miki Motoyama, Koji Ueda, Yoshinori Okamoto, Nakao Kojima
    • Organizer
      12th European Biological Inorganic Chemistry Conference
    • Place of Presentation
      スイス、チューリッヒ
    • Year and Date
      2014-08-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Molecular mechanism analysis of cytotoxicity induced by platinum(IV) complexes against cisplatin-resistant human ovarian cancer2014

    • Author(s)
      戸邊隆夫、清水香琳、本山美貴、植田康次、岡本誉士典、小嶋仲夫
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸
    • Year and Date
      2014-07-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Cytotoxicity of Pt(IV) complexes against cisplatin-resistant human ovarian cancer cells -Potential role of reactive oxygen species-2014

    • Author(s)
      清水崇光、戸邊隆夫、清水香琳、本山美貴、岡本誉士典、植田康次、小嶋仲夫
    • Organizer
      第24回金属の関与する生体関連反応シンポジウムSRM2014
    • Place of Presentation
      京都
    • Year and Date
      2014-06-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 白金4価錯体による酸化的遺伝子損傷および配位子依存性2013

    • Author(s)
      岡本誉士典、臼井健吾、徐 佳典、清水香琳、本山美貴、植田康次、小嶋仲夫
    • Organizer
      第66回日本酸化ストレス学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] Ligand-dependent influx/efflux pattern of Pt(IV) complexes and their relevance to cytotoxicity in human ovarian cancer cells2013

    • Author(s)
      戸邊隆夫、臼井健吾、徐 佳典、植田康次、岡本誉士典、小嶋仲夫
    • Organizer
      第23回金属の関与する生体関連反応シンポジウムSRM2013
    • Place of Presentation
      武蔵野
    • Related Report
      2013 Research-status Report
  • [Presentation] Pt(IV)錯体の配位子依存的がん細胞障害性と細胞内分布挙動2013

    • Author(s)
      清水香琳、戸邊隆夫、臼井健悟、徐 佳典、植田康次、岡本誉士典、小嶋仲夫
    • Organizer
      フォーラム2013:衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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