| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Gadolinium chelate-conjugated dextran (Gd-Dex) was synthesized as a carrier to trace photosensitizer for photodynamic therapy of tumor. Gd-Dex accumulated in a tumor immediately after intravenous injection to a S180 tumor model mouse, whereas it remained in a blood compartment of healthy mouse for more than 60 min. Amount of Gd-Dex accumulation per tumor volume was almost constant in a tumor size 500-3000 mm3 60 min after its intravenous administration. Although Gd-Dex circulated in the blood was excreted from the kidney after receiving hydrolysis, some of Gd-Dex accumulated in the liver. On the other hand, photosensitizer-conjugated dextran was successfully synthesized by the reaction of ethylenediamine-derived chlorin e6 and cyano-derrivatives of dextran. These results are important data for MRI-guided photodynamic therapy of tumor.
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