Development of traceable photosensitizer to produce enough effect of photodynamic therapy
Project/Area Number |
25460053
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Physical pharmacy
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Research Institution | Sojo University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
OKAZAKI Shoko 崇城大学, 薬学部, 講師 (40435152)
|
Project Period (FY) |
2013-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | MRI / デキストラン / クロリンe6 / 腫瘍 / 光線力学療法 / 体内動態 / 造影剤 / ナノ粒子製剤 / 多糖 / 血中滞留性 |
Outline of Final Research Achievements |
Gadolinium chelate-conjugated dextran (Gd-Dex) was synthesized as a carrier to trace photosensitizer for photodynamic therapy of tumor. Gd-Dex accumulated in a tumor immediately after intravenous injection to a S180 tumor model mouse, whereas it remained in a blood compartment of healthy mouse for more than 60 min. Amount of Gd-Dex accumulation per tumor volume was almost constant in a tumor size 500-3000 mm3 60 min after its intravenous administration. Although Gd-Dex circulated in the blood was excreted from the kidney after receiving hydrolysis, some of Gd-Dex accumulated in the liver. On the other hand, photosensitizer-conjugated dextran was successfully synthesized by the reaction of ethylenediamine-derived chlorin e6 and cyano-derrivatives of dextran. These results are important data for MRI-guided photodynamic therapy of tumor.
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Report
(6 results)
Research Products
(28 results)
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[Journal Article] Surface-deacetylated chitin nanofibers reinforced with a sulfobutyl ether β-cyclodextrin gel loaded with prednisolone as potential therapy for inflammatory bowel disease.2017
Author(s)
Tabuchi R, Anraku M, Iohara D, Ishiguro T, Ifuku S, Nagae T, Uekama K, Okazaki S, Takeshita K, Otagiri M, Hirayama F.
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Journal Title
Carbohydrate Polymers
Volume: 174
Pages: 1087-1094
DOI
Related Report
Peer Reviewed
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