| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
In order to cure cancer, it is necessary to eliminate cancer stem cells (CSCs), that is resistant to chemotherapy and radiotherapy in a tumor tissue. Hair follicle stem cells (HFSCs) are cell of origin of cancer in mouse skin cancer model. Interferon regulartory factor 2 (IRF-2) is transcriptional factor which negatively regulate IFN signaling in a cell. In this study, I found that the functional decline of HFSCs was induced by direct and/or indirect effect of physiologic IFNs in vivo in IRF2 deficient mice. Furthermore, based on comprehensive gene expression analysis and lineage tracing experiment, chronic IFN exposure induces “aberrant differentiation” on HFSCs. These effects of IFN may applicable for the strategy to eradicate CSCs.
|
