Molecular action mechanisms of chemical compounds that induce non-proteasomal degradation of beta-catenin
Project/Area Number |
25460069
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Iwate Medical University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
KAWANO Tomikazu 岩手医科大学, 薬学部, 教授 (30283807)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | がん / シグナル伝達 / 分子標的薬 / Wnt / β-catenin / 阻害剤 / リソソーム / Notch |
Outline of Final Research Achievements |
Abnormal activation of the Wnt/beta-catenin pathway observed in malignant tumors has been an attractive target pathway for anticancer therapeutics. In the present study, we studied action mechanism of IMU14 derivatives that we identified as inhibitors of Wnt/beta-catenin pathway. We hypothesized that IMU compounds switch proteasomal beta-catenin degradation to lysosomal proteoyisis, and verified the hypothesis. In addition to in vitro studies, antitumor activity of an IMU compound was analyzed in a dextran sulfate-induced colorectal tumor model in APCMin/+ mice.
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Report
(4 results)
Research Products
(30 results)
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[Presentation] Self-floating cell populations express breast cancer stem cell markers and show resistance to anticancer drugs.2016
Author(s)
(58)Uehara, Y., Oku, Y., Tsuda, K., Shibazaki, M., Maesawa, C., Nishiya, N.
Organizer
AACR-JCA Joint Conference
Place of Presentation
Maui (USA)
Year and Date
2016-02-16
Related Report
Int'l Joint Research
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[Presentation] (48)Nishiya, N., Oku, Y., Uehara, Y. Self-floating breast cancer cells elevate aldehyde dehydrogenase activity and show drug resistance.2015
Author(s)
Nishiya, N., Oku, Y., Uehara, Y.
Organizer
2015 Annual Meeting of the International Society for Stem Cell Research
Place of Presentation
Stockholm (Sweden)
Year and Date
2015-06-24
Related Report
Int'l Joint Research
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[Presentation] Geranylgeranyltransferase inhibitors attenuate the Wnt/beta-catenin signaling pathway.
Author(s)
Nishiya, N., Abe, S., Iwaoka, S., Ohmori, N., Ohnishi, Y., Sasaki, A., Shoji, M., Oku, Y, Uehara, Y.
Organizer
FAOBMB mini symposium 2013
Place of Presentation
紫波郡矢巾町
Related Report
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[Presentation] ROCK-LIMK1 axis activates Aurora A and participates in centrosome integrity.
Author(s)
Oku, Y., Tareyanagi, C., Ujiie, H., Takaya, S., Yoshida, K., Nishiya, N., Uehara, Y.
Organizer
FAOBMB mini symposium 2013
Place of Presentation
紫波郡矢巾町
Related Report
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