| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
To elucidate the mechanisms underlying Src-signaling-mediated regulation of cell division, we demonstrated the involvement of Src tyrosine kinases and their downstream signaling molecules in cell division including spindle formation and chromosome segregation. Furthermore, we established the novel method to synchronize M-phase cells at the anaphase and telophase, and we identified a lot of novel, phosphorylated peptides at this phase. Additionally, by using v-Src as a model protein of aberrantly activated Src, we found that aberrant activation of Src kinase activity induces defect in cell division. We also found the chromosome bridge formation by v-Src possibly through v-Src-induced DNA damage.
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