Regulation of cell division by Src signaling and its role in the cancer malignancy
Project/Area Number |
25460076
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Kyoto Pharmaceutical University |
Principal Investigator |
Nakayama Yuji 京都薬科大学, 薬学部, 教授 (10280918)
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Co-Investigator(Kenkyū-buntansha) |
SAITO YOUHEI 京都薬科大学, 薬学部, 助教 (90411032)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | Src / 細胞分裂 / チロシンリン酸化 / 紡錘体形成 / v-Src |
Outline of Final Research Achievements |
To elucidate the mechanisms underlying Src-signaling-mediated regulation of cell division, we demonstrated the involvement of Src tyrosine kinases and their downstream signaling molecules in cell division including spindle formation and chromosome segregation. Furthermore, we established the novel method to synchronize M-phase cells at the anaphase and telophase, and we identified a lot of novel, phosphorylated peptides at this phase. Additionally, by using v-Src as a model protein of aberrantly activated Src, we found that aberrant activation of Src kinase activity induces defect in cell division. We also found the chromosome bridge formation by v-Src possibly through v-Src-induced DNA damage.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage2014
Author(s)
Yasunori Fukumoto, Mariko Morii, Takahito Miura, Sho Kubota, Kenichi Ishibashi, Takuya Honda, Aya Okamoto, Noritaka Yamaguchi, Atsushi Iwama, Yuji Nakayama, Naoto Yamaguchi
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Journal Title
The Journal of Biological Chemistry
Volume: in press
Issue: 18
Pages: 12313-12329
DOI
Related Report
Peer Reviewed
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