Molecular mechanisms and enhanced inflammtion in retardation of brain development and cognitive impairment in a mouse model of Down synrome
| Project/Area Number |
25460077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KANAI SHIHO 京都薬科大学, 薬学部, 助手 (40582630)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ダウン症 / マウスモデル / オミクス解析 / 炎症 / 神経伝達物質 / 胎仔脳 / 炎症細胞 / 原因遺伝子 / 脳発達 / DNAマイクロアレイ / 炎症性細胞 / プロテオミクス解析 / マイクロアレイ解析 / 記憶学習 |
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| Outline of Final Research Achievements |
To elucidate the pathomechanisms underling intellectual disability and developmental delay of the brain in Down syndrome (DS), we employed three "-omics" analyses. Our proteomics and transcriptomics analysis revealed the perturbated expressions of five proteins, which suggest a disturbance of GABAergic interneurogenesis, and increased expressions of inflammation-related genes in the embryonic brain of a mouse model for DS. In addition, our quantitative analysis for neurotransmitters suggest an increased flux through central dopamine and serotonin metabolism in the adult brain of a DS model mouse. Finally, we succeeded to identify the responsible gene for increased expression of inflammation-related gene in the embryonic brain of a DS model mouse. We assume our findings are important to display the developmental delay and intellectual disability in the individuals with DS.
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.2017
Author(s)
Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K.
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Journal Title
Exp Neurol
Volume: S0014-4886(17)
Pages: 30069-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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