| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
To elucidate the pathomechanisms underling intellectual disability and developmental delay of the brain in Down syndrome (DS), we employed three "-omics" analyses. Our proteomics and transcriptomics analysis revealed the perturbated expressions of five proteins, which suggest a disturbance of GABAergic interneurogenesis, and increased expressions of inflammation-related genes in the embryonic brain of a mouse model for DS. In addition, our quantitative analysis for neurotransmitters suggest an increased flux through central dopamine and serotonin metabolism in the adult brain of a DS model mouse. Finally, we succeeded to identify the responsible gene for increased expression of inflammation-related gene in the embryonic brain of a DS model mouse. We assume our findings are important to display the developmental delay and intellectual disability in the individuals with DS.
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