| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Many factors are involved in the regulation of obesity. PPARγ, a nuclear receptor plays a central role in the regulation of obesity. We identified that the expression of the Elovl3 (Elongation of very long chain fatty acid) gene was activated by PPARγ in adipocytes, and the enzymatic products of Elovl3, C18:1 and C20:1 fatty acids bind with PPARγ as ligands. We also constructed mouse Elovl3 antibody, and used for analysis. Moreover, the Elovl3 KO mice are constructing.
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