| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
To repair functions of the injured heart, a great deal of research has attempted to develop regenerative medicine using pluripotent stem cell–based cardiomyocytes as cell therapy products. Although several cell signals have been reported to play important roles in cardiac differentiation, its detailed molecular mechanism remains unknown. We have previously showed AW551984 as a regulator of cardiomyogenesis, and here identified AW551984-binding proteins (AW551984-BPs), which expressed in embryoid bodies of mouse embryonic stem (ES) cells. We further extracted several AW551984-BPs involved in regulation of cardiomyogenesis in mouse ES cells. We also indicated that human homolog VWA5A modulated in vitro cardiac differentiation of human iPS cells.
|
