Analysis of the mechanism for the cardiomyogenic effect of AW551984 on pluripotent stem cells
| Project/Area Number |
25460083
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | National Institute of Health Sciences |
|---|
Principal Investigator |
Yasuda Satoshi 国立医薬品食品衛生研究所, 再生・細胞医療製品部, 室長 (20381262)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 多能性幹細胞 / 心筋分化 / 発生・分化 / 心筋細胞 |
|---|
| Outline of Final Research Achievements |
To repair functions of the injured heart, a great deal of research has attempted to develop regenerative medicine using pluripotent stem cell–based cardiomyocytes as cell therapy products. Although several cell signals have been reported to play important roles in cardiac differentiation, its detailed molecular mechanism remains unknown. We have previously showed AW551984 as a regulator of cardiomyogenesis, and here identified AW551984-binding proteins (AW551984-BPs), which expressed in embryoid bodies of mouse embryonic stem (ES) cells. We further extracted several AW551984-BPs involved in regulation of cardiomyogenesis in mouse ES cells. We also indicated that human homolog VWA5A modulated in vitro cardiac differentiation of human iPS cells.
|
Report
(4 results)
Research Products
(29 results)
