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The defensive role of immature myeloid cells in severe invasive group A streptococcal infections

Research Project

Project/Area Number 25460085
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Matsumura Takayuki  国立感染症研究所, 免疫部, 主任研究官 (50434379)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords劇症型溶血性レンサ球菌感染症 / IFN-γ / IL-6 / 免疫学 / 細菌感染症
Outline of Final Research Achievements

Group A Streptococcus (GAS) infections range from mild symptoms, such as skin infections, to serious infections including toxic shock syndrome. Neutrophils and myeloid cells are important in protecting against GAS infections. However, during severe invasive GAS infections that accompanied with neutropenia, it had been unclear which factors are protective against such infections, and which cell population is the source of them. Here we show that mice infected with severe invasive GAS isolate exhibit excessive levels of plasma interferon (IFN)-g and interleukin (IL)-6. Interestingly, immature myeloid cells (IMCs) are the source of IFN-g and IL-6 in mice infected with severe invasive GAS isolates. Adoptive transfer of IMCs is successful to improve bacterial clearance and survival rate of mice infected with severe invasive GAS isolate. Our results indicate that IMCs have a defensive role in severe invasive GAS infections.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) (of which Invited: 3 results)

  • [Journal Article] Myeloid-derived suppressor cells (MDSCs) and their related cell subpopulations2013

    • Author(s)
      Takayuki Matsumura, Kazuo Kobayashi, Manabu Ato
    • Journal Title

      The Research and Biology of Cancer I

      Volume: - Pages: 155-172

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] The defensive role of IL-6-producing immature myeloid cells in group A streptococcal infections2016

    • Author(s)
      松村隆之、池辺忠義、大西真、阿戸学
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Immature myeloid cells are the producers of host protective factors in severe invasive group A streptococcal infections2015

    • Author(s)
      Takayuki Maqtsumura, Manabu Ato
    • Organizer
      第44回日本免疫学会総会・学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Immature myeloid cells are the major producers of IL-6 in severe invasive group A streptococcal infections2014

    • Author(s)
      Takayuki Matsumura, Manabu Ato
    • Organizer
      第43回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 劇症型溶血性レンサ球菌感染症における未熟骨髄系細胞の役割2014

    • Author(s)
      松村隆之
    • Organizer
      第15回Pharmaco-Hematology Symposium
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] The defensive role of immature myeloid cells in severe invasive group A Streptococcus infections2014

    • Author(s)
      Takayuki Matsumura, Tadayoshi Ikebe, Manabu Ato
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Interferon-γ-producing immature myeloid cells in severe Streptococcus infection2013

    • Author(s)
      Manabu Ato, Takayuki Matsumura, Tadayoshi Ikebe
    • Organizer
      第78回日本インターフェロン・サイトカイン学会・第21回マクロファージ分子生物学国際シンポジウム合同学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Immature myeloid cells, which produce interferon-γ and/or interleukin-6, play a protective role in severe invasive group A Streptococcus infections2013

    • Author(s)
      Takayuki Matsumura, Tadayoshi Ikebe, Manabu Ato
    • Organizer
      第78回日本インターフェロン・サイトカイン学会・第21回マクロファージ分子生物学国際シンポジウム合同学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 劇症型溶血性レンサ球菌感染症におけるインターフェロンγ産生未熟骨髄系細胞の役割

    • Author(s)
      松村隆之
    • Organizer
      平成25年度北里大学メディカルセンター研究部門学術講演会
    • Place of Presentation
      埼玉
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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