| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Group A Streptococcus (GAS) infections range from mild symptoms, such as skin infections, to serious infections including toxic shock syndrome. Neutrophils and myeloid cells are important in protecting against GAS infections. However, during severe invasive GAS infections that accompanied with neutropenia, it had been unclear which factors are protective against such infections, and which cell population is the source of them. Here we show that mice infected with severe invasive GAS isolate exhibit excessive levels of plasma interferon (IFN)-g and interleukin (IL)-6. Interestingly, immature myeloid cells (IMCs) are the source of IFN-g and IL-6 in mice infected with severe invasive GAS isolates. Adoptive transfer of IMCs is successful to improve bacterial clearance and survival rate of mice infected with severe invasive GAS isolate. Our results indicate that IMCs have a defensive role in severe invasive GAS infections.
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