| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Outline of Final Research Achievements |
In this research, I tried to identify a kinase that changes the phosphorylation state of serine 315 (S315) of ceramide transport protein (CERT) when its expression level is suppressed by transfection of siRNA library. As a result, I showed that suppressed expression of a certain stress-responsive kinase decreased the phosphorylation state of CERT S315. From the information about the kinase, I speculated that an environmental factor might be involved in phospho-regulation of CERT and experimentally showed that the factor critically up-regulated the phosphorylation state of CERT S315.
|
