Research of the regulatory mechanism of CERT-VAP interaction, from the causing factors to the caused effects.
| Project/Area Number |
25460086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
KUMAGAI KEIGO 国立感染症研究所, 細胞化学部, 主任研究官 (40443105)
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| Co-Investigator(Renkei-kenkyūsha) |
HANADA KENTARO 国立感染症研究所, 細胞化学部, 部長 (30192701)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 脂質輸送 / セラミド / スフィンゴミエリン / FFATモチーフ / リン酸化 / メンブレンコンタクトサイト / クラミジア |
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| Outline of Final Research Achievements |
In this research, I tried to identify a kinase that changes the phosphorylation state of serine 315 (S315) of ceramide transport protein (CERT) when its expression level is suppressed by transfection of siRNA library. As a result, I showed that suppressed expression of a certain stress-responsive kinase decreased the phosphorylation state of CERT S315. From the information about the kinase, I speculated that an environmental factor might be involved in phospho-regulation of CERT and experimentally showed that the factor critically up-regulated the phosphorylation state of CERT S315.
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Report
(5 results)
Research Products
(11 results)
