| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Prostaglandin D2 (PGD2) and prostaglandin E2 (PGE2) are known as positional-isomers so that they are known to cross-talk to the other receptors besides its own cognate receptors. However, the physiological roles and/or significances of the cross-talks have been remained unclear. In this study, we have elucidated that PGD2 or PGE2 acts to DP receptors or EP2 receptors not as a partial agonist but as a biased ligand followed by activating a biased signaling pathway, respectively. It is widely reported that PGD2 has a role on anti-cancer activity whereas PGE2 has a pro-cancer activity. The findings about the biased activity evoked by endogenous prostanoids as biased agonists are very significant that may answer the reasons why both prostanoids show the opposite functions in the body. We believe that our study will provide innovated ideas and/or approaches in the field of understanding physiological functions of the G protein-coupled receptors including prostanoid receptors.
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