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Effect of nicotine on reward-based decision-making in healthy and methamphetamine-treated rat

Research Project

Project/Area Number 25460094
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pharmacology in pharmacy
Research InstitutionNagoya University

Principal Investigator

Mizoguchi Hiroyuki  名古屋大学, 環境医学研究所, 助教 (70402568)

Co-Investigator(Renkei-kenkyūsha) YAMADA Kiyofumi  名古屋大学, 医学部附属病院, 教授 (30303639)
YAMANAKA Akihiro  名古屋大学, 環境医学研究所, 教授 (60323292)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords意思決定 / ニコチン / 覚せい剤 / ニコチン受容体
Outline of Final Research Achievements

In this study, we examined the effects of nicotine on reward-based decision-making in healthy and methamphetamine (METH)-treated rat. We analyzed the performance of rats in a gambling test for rodents. Nicotine treatment (0.3 mg/kg) ameliorated the abnormal arm-choice behavior of METH-treated rats in the gambling test. However, chronic nicotine treatment (0.3 or 0.6 mg/kg) did not show changes in arm-choice behavior in healthy rats. Our findings suggest that nicotine may have some therapeutic effects against impairment of decision-making in METH addicts.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2015 2014 2013 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Insular neural system controls decision-making in healthy and methamphetamine-treated rats2015

    • Author(s)
      Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Nakamura A, Wang T, Nagai T, Sato J, Sawada M, Ohira H,Yamanaka A, Yamada K
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 112 (29) Issue: 29 Pages: 3930-3939

    • DOI

      10.1073/pnas.1418014112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid beta-induced memory impairment2014

    • Author(s)
      Fukumoto K, Mizoguchi H, Takeuchi H, Horiuchi H, Kawanokuchi J, Jin, SJ, Mizuno T, Suzumura A
    • Journal Title

      Behavioural brain research

      Volume: 268 Pages: 88-93

    • DOI

      10.1016/j.bbr.2014.03.046

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Nucleus accumbens plays a role in arm choice behavior in the rodent gambling test2015

    • Author(s)
      Mizoguchi H, Inutsuka A, Hikida T, Yamanaka A, Yamada K.
    • Organizer
      2015年包括脳ネットワーク冬のシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Nicotine receptor as a potential target for treatment of pathological decision-making in addiction2015

    • Author(s)
      Mizoguchi H, Yamada K.
    • Organizer
      WPAIC 2015, 4th Asian Congress of Schizophrenia Research, 4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of nicotine on altered decision-making in methamphetamine-treated rat2015

    • Author(s)
      Mizoguchi H, Wang T, Yamada K.
    • Organizer
      International Symposium on Prediction and Decision Making 2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 基礎研究から探る薬物依存者の意思決定:リスク回避より目先の利益を優先する近視眼的意思決定2015

    • Author(s)
      溝口博之、山田清文
    • Organizer
      平成27年度アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] The insular GABAergic system controls decision-making in healthy and drug-dependent animals.2015

    • Author(s)
      Mizoguchi H, Yamada K.
    • Organizer
      IBNS 24th Annual Meeting
    • Place of Presentation
      Victoria
    • Year and Date
      2015-06-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 覚せい剤依存症モデルラットの意思決定障害と島皮質2015

    • Author(s)
      溝口博之、福本和哉、山田清文
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 島皮質は薬物依存症モデルラットの意思決定に関与する2015

    • Author(s)
      溝口博之、山田清文
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 薬物依存症の意思決定異常と島皮質2014

    • Author(s)
      溝口博之、片平健太郎、犬束 歩、大平英樹、山中章弘、山田清文
    • Organizer
      第36回日本生物学的精神医学会、第57回日本神経化学会大会合同年会
    • Place of Presentation
      奈良
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Reward-Based Decision-making in methamphetamine-dependent rat.2014

    • Author(s)
      Mizoguchi H., Fukumoto K., Wang T., Yamada K.
    • Organizer
      9th Federation of European Neuroscience Societies, Forum of Neuroscience
    • Place of Presentation
      ミラノ
    • Year and Date
      2014-07-05 – 2014-07-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Dysfunction of GABAergic system in the insular cortex is associated with impaired decision-making in methamphetamine-treated rats2014

    • Author(s)
      Yamada K., Fukumoto K., Wang T., Mizoguchi H.
    • Organizer
      29th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      バンクーバー
    • Year and Date
      2014-06-22 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Decision making in methamphetamine-treated rat.2013

    • Author(s)
      H. Mizoguchi, K. Fukumoto, T. Wang, J. Sato, K. Yamada
    • Organizer
      The 22rd Annual Meeting of International Behavioral Neuroscience Society
    • Place of Presentation
      ダブリン
    • Related Report
      2013 Research-status Report
  • [Presentation] Neuronal mechanism of impaired decision-making in an animal model of methamphetamine dependence.2013

    • Author(s)
      H. Mizoguchi, K. Yamada
    • Organizer
      International symposium of “Prediction and Decision Making” 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 覚せい剤依存モデル動物の近視眼的意思決定と島皮質障害.

    • Author(s)
      溝口博之、福本和哉、山田清文
    • Organizer
      平成25年度アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] DERADDシステムで報酬に基づく意思決定行動を操作する.

    • Author(s)
      溝口 博之、福本 和哉、犬束 歩、山中 章弘、山田 清文
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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