Effect of nicotine on reward-based decision-making in healthy and methamphetamine-treated rat

• Project/Area Number: 25460094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Nagoya University
• Principal Investigator: Mizoguchi Hiroyuki 名古屋大学, 環境医学研究所, 助教 (70402568)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Kiyofumi 名古屋大学, 医学部附属病院, 教授 (30303639) ; YAMANAKA Akihiro 名古屋大学, 環境医学研究所, 教授 (60323292)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 意思決定 / ニコチン / 覚せい剤 / ニコチン受容体

Outline of Final Research Achievements

In this study, we examined the effects of nicotine on reward-based decision-making in healthy and methamphetamine (METH)-treated rat. We analyzed the performance of rats in a gambling test for rodents. Nicotine treatment (0.3 mg/kg) ameliorated the abnormal arm-choice behavior of METH-treated rats in the gambling test. However, chronic nicotine treatment (0.3 or 0.6 mg/kg) did not show changes in arm-choice behavior in healthy rats. Our findings suggest that nicotine may have some therapeutic effects against impairment of decision-making in METH addicts.

Research Products

• [Journal Article] Insular neural system controls decision-making in healthy and methamphetamine-treated rats (2015)
  • Author(s): Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Nakamura A, Wang T, Nagai T, Sato J, Sawada M, Ohira H,Yamanaka A, Yamada K
  • Journal Title: Proc Natl Acad Sci U S A Volume: 112 (29) Issue: 29 Pages: 3930-3939
  • DOI: 10.1073/pnas.1418014112
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid beta-induced memory impairment (2014)
  • Author(s): Fukumoto K, Mizoguchi H, Takeuchi H, Horiuchi H, Kawanokuchi J, Jin, SJ, Mizuno T, Suzumura A
  • Journal Title: Behavioural brain research Volume: 268 Pages: 88-93
  • DOI: 10.1016/j.bbr.2014.03.046
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Nucleus accumbens plays a role in arm choice behavior in the rodent gambling test (2015)
  • Author(s): Mizoguchi H, Inutsuka A, Hikida T, Yamanaka A, Yamada K.
  • Organizer: 2015年包括脳ネットワーク冬のシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2015-12-17
• [Presentation] Nicotine receptor as a potential target for treatment of pathological decision-making in addiction (2015)
  • Author(s): Mizoguchi H, Yamada K.
  • Organizer: WPAIC 2015, 4th Asian Congress of Schizophrenia Research, 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] Effect of nicotine on altered decision-making in methamphetamine-treated rat (2015)
  • Author(s): Mizoguchi H, Wang T, Yamada K.
  • Organizer: International Symposium on Prediction and Decision Making 2015
  • Place of Presentation: 東京
  • Year and Date: 2015-10-31
  • Int'l Joint Research
• [Presentation] 基礎研究から探る薬物依存者の意思決定：リスク回避より目先の利益を優先する近視眼的意思決定 (2015)
  • Author(s): 溝口博之、山田清文
  • Organizer: 平成27年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-11
• [Presentation] The insular GABAergic system controls decision-making in healthy and drug-dependent animals. (2015)
  • Author(s): Mizoguchi H, Yamada K.
  • Organizer: IBNS 24th Annual Meeting
  • Place of Presentation: Victoria
  • Year and Date: 2015-06-02
  • Int'l Joint Research
• [Presentation] 覚せい剤依存症モデルラットの意思決定障害と島皮質 (2015)
  • Author(s): 溝口博之、福本和哉、山田清文
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 島皮質は薬物依存症モデルラットの意思決定に関与する (2015)
  • Author(s): 溝口博之、山田清文
  • Organizer: 第８８回日本薬理学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] 薬物依存症の意思決定異常と島皮質 (2014)
  • Author(s): 溝口博之、片平健太郎、犬束 歩、大平英樹、山中章弘、山田清文
  • Organizer: 第36回日本生物学的精神医学会、第57回日本神経化学会大会合同年会
  • Place of Presentation: 奈良
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] Reward-Based Decision-making in methamphetamine-dependent rat. (2014)
  • Author(s): Mizoguchi H., Fukumoto K., Wang T., Yamada K.
  • Organizer: 9th Federation of European Neuroscience Societies, Forum of Neuroscience
  • Place of Presentation: ミラノ
  • Year and Date: 2014-07-05 – 2014-07-09
• [Presentation] Dysfunction of GABAergic system in the insular cortex is associated with impaired decision-making in methamphetamine-treated rats (2014)
  • Author(s): Yamada K., Fukumoto K., Wang T., Mizoguchi H.
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: バンクーバー
  • Year and Date: 2014-06-22 – 2014-06-26
• [Presentation] Decision making in methamphetamine-treated rat. (2013)
  • Author(s): H. Mizoguchi, K. Fukumoto, T. Wang, J. Sato, K. Yamada
  • Organizer: The 22rd Annual Meeting of International Behavioral Neuroscience Society
  • Place of Presentation: ダブリン
• [Presentation] Neuronal mechanism of impaired decision-making in an animal model of methamphetamine dependence. (2013)
  • Author(s): H. Mizoguchi, K. Yamada
  • Organizer: International symposium of “Prediction and Decision Making” 2013
  • Place of Presentation: 京都
• [Presentation] 覚せい剤依存モデル動物の近視眼的意思決定と島皮質障害.
  • Author(s): 溝口博之、福本和哉、山田清文
  • Organizer: 平成25年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 岡山
  • Invited
• [Presentation] DERADDシステムで報酬に基づく意思決定行動を操作する.
  • Author(s): 溝口 博之、福本 和哉、犬束 歩、山中 章弘、山田 清文
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台