Role of the 5-HT4 receptor in neurogenic activity of chronic fluoxetine in the dentate gyrus and its association with mature granule cell dematuration
Project/Area Number |
25460096
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pharmacology in pharmacy
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Research Institution | Tokyo University of Science (2015) Kyoto University (2013-2014) |
Principal Investigator |
SEGI ERI 東京理科大学, 基礎工学部, 准教授 (70378628)
|
Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI KATSUNORI 日本医科大学, 医学部, 准教授 (10322041)
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Research Collaborator |
IMOTO YUKI
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 海馬 / 抗うつ薬 / 神経神経 / セロトニン受容体 / 神経新生 |
Outline of Final Research Achievements |
Chronic treatment with selective serotonin (5-HT) reuptake inhibitors (SSRIs) facilitates adult neurogenesis in the dentate gyrus (DG) of the hippocampus. However, it is largely unknown how the 5-HT4 receptor mediates neurogenic effects in the DG. I addressed this issue using 5-HT4 receptor knockout (5-HT4R KO) mice. Expression of the 5-HT4 receptor was detected in mature GCs but not in neuronal progenitors of the DG. Chronic treatment with the SSRI fluoxetine significantly increased cell proliferation and the number of doublecortin-positive cells in the DG of wild-type mice, but not in 5-HT4R KO mice. I also demonstrated that fluoxetine-induced adult neurogenesis and granule cell dematuration are closely associated, providing new insight into the cellular mechanisms of the neurogenic actions of SSRIs in the hippocampus.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.2014
Author(s)
Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., and Sugimoto, Y.
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Journal Title
J. Immunol.
Volume: 192
Issue: 3
Pages: 1130-1137
DOI
Related Report
Peer Reviewed
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[Journal Article] Electroconvulsive seizure-induced changes in gene expression in the mouse hypothalamic paraventricular nucleus.2013
Author(s)
Segi-Nishida, E., Sakaida, M., Sukeno, M., Imoto, Y., Kira, T., Tsuchiya, S., Sugimoto, Y., Okuno, Y.
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Journal Title
J. Psychopharmacol.
Volume: 27
Issue: 11
Pages: 1058-1069
DOI
Related Report
Peer Reviewed
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