Analysis and modeling of the effect of microenvironment on tumor growth.

• Project/Area Number: 25460097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Tohoku University
• Principal Investigator: SAITO Sakae 東北大学, 東北メディカル・メガバンク機構, 講師 (20335491)
• Co-Investigator(Kenkyū-buntansha): NAGAYAMA Katsuya 九州工業大学, 大学院情報工学研究院, 准教授 (70363398)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 癌 / ストレス

Outline of Final Research Achievements

Tumor microenvironment is composed of non-cancer cells, such as vascular endothelial cells and immune cells, which are exposed to hypoxic and nutritional stress in tumor. The cellular stress response plays an important role in cell survival under stress conditions and results in tumor progression. To show the impact of microenvironment on tumor growth and morphology, we disclosed the intra-tumor heterogeneity by single cell analysis, and presented a numerical model for tumor growth and angiogenesis.

Research Products

• [Presentation] Integrated genomic characterization of non-small cell lung cancer cell lines. (2016)
  • Author(s): Saito, S., Motoike, I.N., Kinoshita, K., Yasuda, J., Ishii, H., Yamamoto, M.
  • Organizer: Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research
  • Place of Presentation: Maui, Hawaii USA
  • Year and Date: 2016-02-16
• [Presentation] 統合オミクス解析に向けた非小細胞肺がん細胞株のゲノム多型解析 (2015)
  • Author(s): 齋藤さかえ、元池育子、潘小青、齊藤智、齋藤るみ子、檀上稲穂、鈴木隆史、本橋ほづみ、木下賢吾、安田純、石井啓文、山本雅之
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] 腫瘍内細胞のシングルセル解析 (2015)
  • Author(s): 齋藤さかえ、永山勝也
  • Organizer: NGS現場の会 第4回研究会
  • Place of Presentation: つくば国際会議場（茨城県・つくば市）
  • Year and Date: 2015-07-01
• [Presentation] Particle Simulation on Cancer Growth and Angiogenesis- Modeling of stromal cells (2015)
  • Author(s): Yukio Nagamizu, Youhei Tajima, Katsuya Nagayama, Ichiro Miura, Sakae Saito
  • Organizer: The Third BMIRC International Symposium for Virtual Physiological Human
  • Place of Presentation: のがみプレジデントホテル（福岡県飯塚市）
  • Year and Date: 2015-03-05 – 2015-03-06
• [Presentation] 腫瘍成長と血管新生の3D粒子シミュレーション -壊死に関する研究- (2014)
  • Author(s): 永山勝也, 齋藤さかえ, 三浦一郎, 立野玲子, 小倉潔
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] RNA sequencing and whole transcriptome analysis of tumor-associated monocytes. (2014)
  • Author(s): Sakae Saito
  • Organizer: Joint Meeting of the 1st Africa International Biotechnology & Biomedical Conference and the 8th International Workshop on Approaches to Single-Cell Analysis
  • Place of Presentation: Safari Park Hotel (Nairobi, Kenya)
  • Year and Date: 2014-09-09 – 2014-09-12
• [Presentation] Particle simulation of cancer growth and angiogenesis ─ based on the image of mouse (2014)
  • Author(s): Hiroto Tanaka, Yuki Oshiumi, Katsuya Nagayama, Ichiro Miura, Sakae Saito
  • Organizer: The Second BMIRC International Symposium on Advances in Bioinformatics and Medical Engineering: In Memory of Professor Akinori Sarai
  • Place of Presentation: 福岡県立飯塚研究開発センター（福岡県飯塚市）
• [Presentation] 腫瘍増殖の3次元粒子シミュレーション－細胞増殖と血管新生の相互作用モデル (2013)
  • Author(s): 永山勝也, 三浦一郎, 齋藤さかえ, 立野玲子, 小倉潔
  • Organizer: 日本癌学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Remarks] 永山研究室ホームページ
  • URL: http://www.nl.mse.kyutech.ac.jp/07_cancer.htm