| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Recent evidence implicates that abnormalities in dendritic spines are key substrates in the pathogenesis of several neuropsychiatric disorders. In this study, we analyzed the molecular mechanism for the spine maturation and spinogenesis by PACAP signaling. Here, we observed that miR-132 sponge and the MEK1/2 inhibitor U0126 blocked the PACAP-mediated increase in spine maturation and spinogenesis. In contrast, overexpression of miR-132 partly rescued the spine reductions in the PACAP-deficient primary neurons.
These data indicate that PACAP-miRNA132 signaling pathway is critically implicated in spine formation and contribute to understand the molecular mechanisms underlying neuropsychiatric disorders such as schizophrenia.
|
