Elucidation of the treatment against metabolic syndrome by regulating endoplasmic reticulum function
| Project/Area Number |
25460101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
Hosoi Toru 広島大学, 医歯薬保健学研究院(薬), 准教授 (40379889)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | レプチン / 小胞体ストレス |
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| Outline of Final Research Achievements |
Obesity is associated with metabolic syndrome such as hypertension, diabetes, and hyperlipidemia. In the present study, we analyzed the mechanisms and pharmacological treatment against obesity focusing on leptin resistance, which is known to be involved in the pathophysiology of obesity. We found that glial cells may be involved in the leptin signaling in neuronal cells. Furthermore, we found novel mechanisms of leptin resistance caused by ER stress and other factors. These results would be useful information for elucidating strategy for the treatment of metabolic syndrome.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] TERT attenuated ER stress-induced cell death.2014
Author(s)
Hosoi, T., Inoue, Y., Nakatsu, K., Matsushima, N., Kiyose, N., Shimamoto, A., Tahara, H. & Ozawa, K.
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Journal Title
Biochem Biophys Res Commun
Volume: 447
Issue: 2
Pages: 378-382
DOI
Related Report
Peer Reviewed / Open Access
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