| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Obesity is associated with metabolic syndrome such as hypertension, diabetes, and hyperlipidemia. In the present study, we analyzed the mechanisms and pharmacological treatment against obesity focusing on leptin resistance, which is known to be involved in the pathophysiology of obesity. We found that glial cells may be involved in the leptin signaling in neuronal cells. Furthermore, we found novel mechanisms of leptin resistance caused by ER stress and other factors. These results would be useful information for elucidating strategy for the treatment of metabolic syndrome.
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