Study of oxydative stress sensor DJ-1 for therapeutic target of neurodegenerative diseases
| Project/Area Number |
25460109
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Ritsumeikan University (2015)
Kyoto Pharmaceutical University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | DJ-1タンパク質 / DJ-1結合化合物 / パーキンソン病 / アルツハイマー病 / 神経変性疾患 / 抗酸化作用 / ニコチン受容体 / DJ-1結合タンパク質 / 神経保護 / 神経再生 / 多能性幹細胞 |
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| Outline of Final Research Achievements |
Oxidative stress is one of the causes of neurodegenerative diseases, such as Parkinson's (PD) and Alzheimer's diseases (AD). Since symptomatic disease therapies are used, identification of compounds or proteins that inhibit oxidative stress-induced neuronal cell death is necessary. DJ-1 is a causative gene product of familial PD and plays a role in anti-oxidative stress reaction. Recently, we have identified some DJ-1-binding compounds. In this study, wild-type and DJ-1-knockout mice were injected intraperitoneally with DJ-1-binding compounds in the presence or absencs of neurotoxin MPTP. This research showed that DJ-1-binding compounds inhibited MPTP-induced reduction of retention time on the rotor rod bar, neuronal cell death in the substantia nigra and striatum and dopamine content in wild-type mice but not in DJ-1-knockout mice. From these results suggest that DJ-1 is one of novel therapeutic molecular targets for neurodegenerative diseases.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Pharmacological assessment of methamphetamine-induced behavioral hyperactivity mediated by dopaminergic transmission in planarian Dugesia japonica.2014
Author(s)
Natsuka Tashiro, Kaneyasu Nishimura, Kanako Daido, Tomoe Oka, Mio Todo, Asami Toshikawa, Jun Tsushima, Kazuyuki Takata, Kanji Yoshimoto, Kiyokazu Agata, and Yoshihisa Kitamura
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 449 (4)
Pages: 412-418
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Cancer cell tropism of glioblastoma-derived exosomes regulated by their lipid components.2014
Author(s)
Yuki Toda, Kazuyuki Takata, Yuko Nakagawa, Hikaru Kawakami, Shusuke Fujioka, Kazuya Kobayashi, Yasunao Hattori, Yoshihisa Kitamura, Kenichi Akaji, and Eishi Ashihara
Organizer
FEBS EMBO 2014
Place of Presentation
Paris, France
Year and Date
2014-08-30 – 2014-09-04
Related Report
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