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Acid-sensitive K+ channels as threrapeutic targets for immune diseases and cancers

Research Project

Project/Area Number 25460111
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pharmacology in pharmacy
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

Ohya Susumu  京都薬科大学, 薬学部, 教授 (70275147)

Co-Investigator(Kenkyū-buntansha) FUJII Masanori  京都薬科大学, 薬学部, 准教授 (40434667)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsイオンチャネル / カリウムチャネル / 炎症性腸疾患 / Tリンパ球 / スプライシング阻害 / 癌細胞増殖 / 炎症腸疾患 / pH感受性カリウムチャネル / K2P5.1 / 選択的スプライシング / スプライシング阻害剤 / 機能制御分子 / リンパ球 / K2P5.1
Outline of Final Research Achievements

The two-pore domain K+ (K2P) channels are possible therapeutic targets for autoimmune diseases and several cancers. We elucidate the pathological significance of the K2P5.1 K+ channel in inflammatory bowel disease (IBD). Significant upregulation of K2P5.1 K+ channel were observed in the CD4+ T cells of the IBD model. The knockout of K2P5.1 in mice significantly suppressed the disease severity in the IBD model. Additionally, we identified an N-terminus-lacking, novel splicing isoform of K2P5.1 K+ channel, K2P5.1B from the human lymphoid tissues. In a heterologous expression system, K2P5.1B inhibited the plasma membrane trafficking of K2P5.1A. The pre-mRNA splicing inhibitor significantly enhanced the expression levels of K2P5.1B in human leukemic K562 cells, resulting in decrease in the K2P5.1 activity. The pre-mRNA splicing mechanism underlying the posttranscriptional regulation of K2P5.1 K+ channel may be a new therapeutic strategy for autoimmune diseases and cancers.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (60 results)

All 2016 2015 2014 2013 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Acknowledgement Compliant: 3 results,  Open Access: 4 results) Presentation (35 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (12 results)

  • [Journal Article] Physiological Role of K<sup>+</sup> Channels in the Regulation of T Cell Function2016

    • Author(s)
      Ohya S
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 136 Issue: 3 Pages: 479-483

    • DOI

      10.1248/yakushi.15-00246-4

    • NAID

      130005131242

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2016-03-01
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent advances in therapeutic strategies that focus on the regulation of ion channel expression2016

    • Author(s)
      Ohya S, Kito H, Hatano N, Muraki K
    • Journal Title

      Pharmacology & Therapeutics

      Volume: 160 Pages: 11-43

    • DOI

      10.1016/j.pharmthera.2016.02.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of the Ca2+-activated K+ channel KCa3.1 by histone deacetylase inhibition in human breast cancer cells.2016

    • Author(s)
      Ohya, S Kanatsuka, N Hatano, H Kito, A Matsui, M Fujimoto, S Matsuba, S Niwa, P Zhan, T Suzuki & K Muraki.
    • Journal Title

      Pharmacol Res & Persp

      Volume: 4(2) Issue: 2

    • DOI

      10.1002/prp2.228

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular identification of the dominant-negative, splicing isoform of the two-pore domain K+ channel K2P5.1 in lymphoid cells and enhancement of its expression by splicing inhibition2015

    • Author(s)
      Endo K, Kurokawa N, Kito H, Nakakura S, Fujii M, Ohya S
    • Journal Title

      Biochemical Pharmacology

      Volume: 98 Issue: 3 Pages: 440-452

    • DOI

      10.1016/j.bcp.2015.10.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pathophysiological significance of the two-pore domain K(+) channel K2P5.1 in splenic CD4(+)CD25(-) T cell subset from a chemically-induced murine inflammatory bowel disease model.2015

    • Author(s)
      Nakakura S, Matsui M, Sato A, Ishii M, Endo K, Muragishi S, Murase M, Kito H, Niguma H, Kurokawa N, Fujii M, Araki M, Araki K, Ohya S.
    • Journal Title

      Frontiers in Physiology

      Volume: 6 Pages: 299-299

    • DOI

      10.3389/fphys.2015.00299

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Downregulation of Ca2+-activated Cl- channel TMEM16A by the inhibition of histone deacetylase in TMEM16A-expressing cancer cells2015

    • Author(s)
      Matsuba S, Miwa S, Muraki K, Kanatsuka S, Nakazuno Y, Hatano N, Fujii M, Zhan P, Suzuki T, Ohya S
    • Journal Title

      Journal of Pharmacology & Experimental Therapeutics

      Volume: 351 Issue: 3 Pages: 510-518

    • DOI

      10.1124/jpet.114.217315

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Up-regulation of KCa3.1 K^+ channel in mesenteric lymph node CD4^+ T-lymphocytes from a mouse model of dextran sodium sulfate-induced inflammatory bowel disease2014

    • Author(s)
      Ohya S, Fukuyo Y, Kito H, Shibaoka R, Matsui M, Niguma H, Maeda Y, Yamamura H, Fujii M, Kimura K, Imaizumi Y
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: in press Issue: 10 Pages: G873-G885

    • DOI

      10.1152/ajpgi.00156.2013

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intermediate-conductance Ca2+-activated K+ channel KCa3.1 and its related molecules in T-lymphocytes2014

    • Author(s)
      Ohya S, Imaizumi Y
    • Journal Title

      Inflammation & Cell Signaling

      Volume: 1

    • DOI

      10.14800/ics.327

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of the KCa3.1 K^+ channel in auricular lymph node CD4^+ T-lymphocyte function of the delayed-type hypersensitivity model2013

    • Author(s)
      Ohya S, Nakamura E, Horiba S, Kito H, Matsui M, Yamamura H, Imaizumi Y
    • Journal Title

      Br J Pharmacol

      Volume: 169(5) Issue: 5 Pages: 1011-23

    • DOI

      10.1111/bph.12215

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overactive bladder mediated by accelerated Ca^<2+> influx mode of Na^+/Ca^<2+> exchanger in smooth muscle2013

    • Author(s)
      Yamamura H, Cole WC, Kita S, Hotta S, Murata H, Suzuki Y, Ohya S, Iwamoto T, Imaizumi Y
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 305(3) Issue: 3 Pages: C299-C308

    • DOI

      10.1152/ajpcell.00065.2013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhancement of Ca^<2+> influx and ciliary beating by membrane hyperpolarization due to ATP-sensitive K^+ channel opening in mouse airway epithelial cells2013

    • Author(s)
      Ohba T, Sawada E, Suzuki Y, Yamamura H, Ohya S, Tsuda H, Imaizumi Y
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 347(1) Issue: 1 Pages: 145-53

    • DOI

      10.1124/jpet.113.205138

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] New Screening System for Selective Blockers of Voltage-Gated K<sup>+</sup> Channels Using Recombinant Cell Lines Dying Upon Single Action Potential2013

    • Author(s)
      Fujii M, Hayashi K, Ohya S, Yamamura H, Imaizumi Y
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 123 Issue: 2 Pages: 147-158

    • DOI

      10.1254/jphs.13063FP

    • NAID

      130003382590

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Caveolin-1 facilitates the direct coupling between large-conductance Ca^<2+>-activated K^+ (BK_<Ca>) and Cav1.2 Ca^<2+> channels and their clustering to regulate membrane excitability in vascular myocytes2013

    • Author(s)
      Suzuki Y, Yamamura H, Ohya S, Imaizumi Y
    • Journal Title

      J Biol Chem

      Volume: 288(51) Issue: 51 Pages: 36750-61

    • DOI

      10.1074/jbc.m113.511485

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 上皮増殖因子受容体HER2陽性ヒト乳癌細胞におけるカルシウム活性化クロライドチャネルANO1阻害によるHER2転写抑制2016

    • Author(s)
      藤本万由,松葉紗代,井上隆浩,鬼頭宏彰,大矢進
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] デキストラン硫酸ナトリウム誘発性炎症性腸疾患モデルマウスのCD4陽性T細胞における背景カリウムチャネルK2P5.1の発現・活性増大とK2P5.1ノックアウトによる症状の軽減2016

    • Author(s)
      村瀬実希,中倉佐和,村岸沙也加,佐藤綾,遠藤京子,鬼頭宏彰,藤井正徳,大矢進
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性化CD4陽性T細胞におけるスプライシング阻害剤による背景K+チャネルK2P5.1活性制御2016

    • Author(s)
      たぎし和隆,清水彩夏,遠藤京子,鬼頭宏彰,藤井正徳,大矢進
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 上皮増殖因子受容体HER2陽性乳癌細胞におけるカルシウム活性化クロライドチャネルANO1阻害によるHER2転写抑制2016

    • Author(s)
      大矢進,松葉紗代,井上隆浩,中園裕利華,藤本万由
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] T細胞におけるpre-mRNAスプライシング阻害剤による背景カリウムチャネルK2P5.1活性抑制2016

    • Author(s)
      遠藤京子,たぎし和隆,清水彩夏,鬼頭宏彰,藤井正徳,大矢進
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 乳がん細胞におけるヒストン脱アセチル化酵素によるカルシウム活性化カリウムチャネル転写制御2015

    • Author(s)
      金塚早希,波多野紀行,松井梓,松葉紗代,Anowara Khatun,足野晋平,鬼頭宏彰,丹羽里実,藤井正徳,鈴木孝禎,村木克彦,大矢進
    • Organizer
      第128回日本薬理学会近畿部会
    • Place of Presentation
      大阪
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] K562細胞におけるスプライシング阻害剤によるtwo-pore型K+チャネルK2P5.1発現・活性調節2015

    • Author(s)
      清水彩夏,遠藤京子,タギシ和隆,大和優介,黒川なつ美,鬼頭宏彰,藤井正徳,大矢進
    • Organizer
      第65回日本薬学会近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス制御性Tリンパ球におけるCa2+活性化K+チャネルKCa3.1阻害剤in vivo投与によるIL-10転写促進2015

    • Author(s)
      渡辺絢音,仁熊宏樹,松井未来,山田隆弘,鬼頭宏彰,藤井正徳,大矢進
    • Organizer
      第65回日本薬学会近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト乳癌細胞株YMB-1におけるHDAC阻害剤及び活性化ビタミンD3によるイオンチャネル転写制御2015

    • Author(s)
      松井梓,金塚早希,波多野紀行,Anowara Khatun,松葉紗代,丹羽里実,鬼頭宏彰,藤井正徳,村木克彦,鈴木孝禎,大矢進
    • Organizer
      第65回日本薬学会近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] pre-mRNAスプライシング阻害によるTリンパ球two-pore型K+チャネルK2P5.1活性制御2015

    • Author(s)
      遠藤京子,黒川なつ美,鬼頭宏彰,藤井正徳,大矢進
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2015
    • Place of Presentation
      東京
    • Year and Date
      2015-08-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Current topics in cancer research2015

    • Author(s)
      Ohya S
    • Organizer
      1st International Annual AS4QoL Meeting
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-08-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Downregulation of Ca2+-activated Cl- channel TMEM16A by histone deacetylase inhibition in breast cancer cells2015

    • Author(s)
      Ohya S
    • Organizer
      World Congress on Breast Cancer
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      2015-08-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] pH感受性K+チャネルK2P5.1発現阻害によるデキストラン硫酸ナトリウム誘発性炎症性腸疾患症状の改善2015

    • Author(s)
      村岸沙也加,中倉佐和,佐藤 綾,石井瑞紀,村瀬実希,田中涼,遠藤京子,黒川なつ美,鬼頭宏彰,藤井正徳,大矢進
    • Organizer
      第127回日本薬理学会近畿部会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Spliceosome阻害薬によるpH感受性K+チャネルTASK2発現・活性制御2015

    • Author(s)
      遠藤京子,黒川なつ美,中倉佐和,石井瑞紀,鬼頭宏彰,藤井正徳,大矢 進
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Two-pore型K+チャネルK2P5.1選択的スプライシング体の生理学的意義2015

    • Author(s)
      遠藤京子,黒川なつ美,中倉佐和,佐藤 綾,石井瑞紀,鬼頭宏彰,丹羽里実,藤井正徳,大矢 進
    • Organizer
      第92回日本生理学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 炎症性腸疾患の脾臓由来CD4陽性T細胞におけるtwo-pore型K+チャネルK2P5.1の発現・機能解析2015

    • Author(s)
      佐藤 綾,中倉佐和,石井瑞紀,遠藤京子,黒川なつ美,鬼頭宏彰,丹羽里実,藤井正徳,大矢 進
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Two-pore型K+チャネルK2P5.1ドミナントネガティブ体の機能解析と発現制御2015

    • Author(s)
      遠藤京子,黒川なつ美,中倉佐和,鬼頭宏彰,丹羽里実,藤井正徳,大矢 進
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Identification and functional role of the dominant-negative splice variant of pH-sensitive, two-pore domain K+ channel K2P5.12014

    • Author(s)
      Kyoto Endo, Natsumi Kurokawa, Sawa Nakakura, Mizuki Ishii, Masanori Fujii, Susumu Ohya
    • Organizer
      The 45th NIPS International Symposium
    • Place of Presentation
      岡崎、愛知
    • Year and Date
      2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Down-regulation of Ca2+-activated Cl- channel TMEM16A by the inhibition of histone deacetylase in TMEM16A-expressing breast cancer cells2014

    • Author(s)
      Sayo Matsuba, Satomi Niwa, Saki Kanatsuka, Yurika Nakazono, Katsuhiko Muraki, Noriyuki Hatano, Masanori Fujii, Peng Zhan, Takayoshi Suzuki, Susumu Ohya
    • Organizer
      The 45th NIPS International Symposium
    • Place of Presentation
      岡崎、愛知
    • Year and Date
      2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒト乳がん細胞株におけるヒストン脱アセチル化酵素阻害によるCa2+活性化Cl-チャネルTMEM16A発現調節機構2014

    • Author(s)
      松葉紗代,金塚早希,中園裕利華,丹羽里実,藤井正徳,鈴木孝禎,大矢 進
    • Organizer
      第126回日本薬理学会近畿部会
    • Place of Presentation
      和歌山
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 炎症性腸疾患モデルマウスの脾臓由来CD4陽性T細胞におけるアルカリpH活性化K+チャネルTASK2の役割2014

    • Author(s)
      佐藤 綾,中倉佐和,石井瑞紀,丹羽里実,藤井正徳,大矢 進
    • Organizer
      第64回日本薬学会近畿支部大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 症性腸疾患モデルマウスのCD4陽性T細胞におけるtwo-pore型 K+チャネルTASK2の役割2014

    • Author(s)
      中倉佐和,石井瑞紀,佐藤 綾,丹羽里実,藤井正徳,大矢 進
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2014
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒト乳がん細胞株におけるヒストン脱アセチル化酵素阻害剤によるCa2+活性化Cl-チャネルTMEM16A発現・活性抑制2014

    • Author(s)
      松葉紗代,金塚早希,中園裕利華,丹羽里実,村木克彦,波多野紀行,藤井正徳,鈴木孝禎,大矢 進
    • Organizer
      生体機能と創薬シンポジウム2014
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 炎症性腸疾患モデルマウスの腸間膜リンパ節CD4陽性T細胞におけるCa2+活性化K+チャネルKCa3.1活性化因子NDPK-Bリン酸化酵素の役割2014

    • Author(s)
      松井未来,仁熊宏樹,柴岡里奈,村岸沙也加,村瀬実希,藤井正徳,奈邉 健,今泉祐治,大矢 進
    • Organizer
      生体機能と創薬シンポジウム2014
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 炎症性腸疾患モデルマウスのCD4陽性リンパ球におけるtwo-pore型カリウムチャネルTASK2 (K2P5.1) の発現・機能亢進2014

    • Author(s)
      中倉佐和,石井瑞紀,佐藤 綾,丹羽里実,藤井正徳,大矢 進
    • Organizer
      第125回日本薬理学会近畿部会
    • Place of Presentation
      岡山
    • Year and Date
      2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 炎症性腸疾患モデルマウスの腸間膜リンパ節CD4陽性リンパ球におけるカルシウム活性化カリウムチャネルKCa3.1活性化機構における機能制御分子の役割2014

    • Author(s)
      柴岡里奈,松井未来,福与由香,仁熊宏樹,藤井正徳,山村寿男,今泉祐治,大矢進
    • Organizer
      日本薬学会 第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 炎症性腸疾患モデルマウスの脾臓CD4陽性リンパ球におけるtwo-pore型カリウムチャネルTASK2 (K2P5.1) のup-regulation2014

    • Author(s)
      石井瑞紀,中倉佐和,松葉紗代,藤井正徳,大矢進
    • Organizer
      日本薬学会 第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒストン脱アセチル化酵素阻害剤によるカルシウム活性化クロライドチャネルTMEM16A転写・活性の抑制2014

    • Author(s)
      松葉紗代,丹羽里実,四辻健人,藤井正徳,波多野紀行,村木克彦,鈴木孝禎,大矢進
    • Organizer
      日本薬学会 第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 選択的スプライシングによる酸感受性カリウムチャネルTASK2活性制御2014

    • Author(s)
      黒川なつ美,遠藤京子,石井瑞紀,中倉佐和,藤井正徳,奈邉健,大矢進
    • Organizer
      日本薬学会 第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 酸感受性カリウムチャネル選択的スプライシング体による白血病細胞株K562増殖制御2013

    • Author(s)
      遠藤京子,黒川なつ美,石井瑞紀,中倉佐和,藤井正徳,奈邉健,大矢進
    • Organizer
      第123回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 酸感受性カリウムチャネルK2P5.1選択的スプライシング変異体の同定と機能解析2013

    • Author(s)
      遠藤京子,黒川なつ美,石井瑞紀,中倉佐和,藤井正徳,奈邉健,大矢進
    • Organizer
      生体機能と創薬シンポジウム2013
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 酸感受性カリウムチャネル選択的スプライシング変異体の機能的役割2013

    • Author(s)
      遠藤京子,黒川なつ美,石井瑞紀,中倉佐和,藤井正徳,奈邉健,大矢進
    • Organizer
      第63回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 炎症性腸疾患モデルマウスの腸間膜リンパ節Tリンパ球におけるカルシウム活性化カリウムチャネルの役割2013

    • Author(s)
      大矢進,福与由香,松井未来,柴岡里奈,仁熊宏樹,鬼頭宏彰,前田康博,山村寿男,藤井正徳,木村和哲,今泉祐治
    • Organizer
      第63回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Role of the intermediate-conductance Ca2+-activated K+ channel, KCa3.1 in CD4+ T-lymphocytes of mesenteric lymph node of mice inflammatory bowel disease model2013

    • Author(s)
      Ohya S, Fukuyo Y, Matsui M, Yamamura H, Shibaoka R, Niguma H, Fujii M, Imaizumi Y
    • Organizer
      IUPS2013
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Research-status Report
  • [Presentation] 癌細胞株におけるヒストン脱アセチル化酵素阻害剤によるCa2+活性化Cl-チャネル転写・活性制御2013

    • Author(s)
      松葉紗代,丹羽里実,藤井正徳,鈴木孝禎,大矢進
    • Organizer
      第124回日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Remarks] 京都薬科大学

    • URL

      http://www.kyoto-phu.ac.jp/

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Remarks] 京都薬科大学(英語版)

    • URL

      http://www.kyoto-phu.ac.jp/english/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都薬科大学薬理学分野(概要)

    • URL

      http://www.kyoto-phu.ac.jp/education_research/laboratory/cat3/post_23.html

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Remarks] 京都薬科大学薬理学分野(研究室ホームページ)

    • URL

      http://labo.kyoto-phu.ac.jp/yakuri/index.html

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Remarks] 京都薬科大学薬理学分野(概要)(英語版)

    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都薬科大学(英語)

    • URL

      http://www.kyoto-phu.ac.jp/english/

    • Related Report
      2014 Research-status Report
  • [Remarks] 京都薬科大学薬理学分野(英語)(概要)

    • URL

      http://www.kyoto-phu.ac.jp/english/laboratories/cat3/department_of_pharmacology.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 京都薬科大学

    • URL

      http://www.kyoto-phu.ac.jp/

    • Related Report
      2013 Research-status Report
  • [Remarks] 京都薬科大学(英語)

    • URL

      http://www.kyoto-phu.ac.jp/english/

    • Related Report
      2013 Research-status Report
  • [Remarks] 研究室(概要)

    • URL

      http://www.kyoto-phu.ac.jp/education_research/laboratory/cat3/post_23.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 研究室ホームページ

    • URL

      http://labo.kyoto-phu.ac.jp/yakuri/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 研究室(概要)(英語)

    • URL

      http://www.kyoto-phu.ac.jp/english/laboratories/cat3/department_of_pharmacology.html

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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