Semaphorin 7A plays a critical role in airway inflammation
| Project/Area Number |
25460112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | セマフォリン / 喘息 / セマフォリン7A / Plexin C1 / アレルギー / 好中球 / サイトカイン / ケモカイン / セマフォリン７Ａ / セマフォリン３Ａ / 好酸球 |
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| Outline of Final Research Achievements |
Elevated allergen-specific IgE levels are a hallmark of allergic asthma, a disease involving chronic airway inflammation characterized by airway hyperresponsiveness (AHR); neutrophilic airway inflammation is found in patients with severe asthma. Meanwhile, semaphorins regulating neuronal and immune function have been focused on in several diseases. Here, we investigated whether semaphorin 7A (SEMA7A) is related to IgE-mediated neutrophilic inflammation in mice. Our results highlight the importance of SEMA7A for neutrophilic airway inflammation, which is related to the development of AHR, in IgE-sensitized mice, indicating critical steps of leukocyte infiltration in vivo. The efficacy of functional blockage of SEMA7A may offer a new therapeutic approach in the treatment of severe and/or chronic allergic asthma associated with neutrophilic airway inflammation.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Production of interleukin (IL)-33 in the lungs during multiple antigen challenge-induced airway inflammation in mice, and its modulation by a glucocorticoid2015
Author(s)
Takeshi Nabe, Hiroki Wakamori, Chihiro Yano, Ayumi Nishiguchi, Rino Yuasa, Hitomi Kido, Yusaku Tomiyama, Ayumi Tomoda, Haruka Kida, Anna Takiguchi, Masaya Matsuda, Keiichi Ishihara, Satoshi Akiba, Susumu Ohya, Hiroyuki Fukui, Nobuaki Mizutani, Shin Yoshino
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Journal Title
European Journal of Pharmacology
Volume: 757
Pages: 34-41
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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